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Uncovering the mode of action of engineered T cells in patient cancer organoids.
Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, Puschhof J, Brazda P, Johanna I, Meringa AD, Rebel HG, Buchholz MB, Barrera Román M, Zeeman AL, de Blank S, Fasci D, Geurts MH, Cornel AM, Driehuis E, Millen R, Straetemans T, Nicolasen MJT, Aarts-Riemens T, Ariese HCR, Johnson HR, van Ineveld RL, Karaiskaki F, Kopper O, Bar-Ephraim YE, Kretzschmar K, Eggermont AMM, Nierkens S, Wehrens EJ, Stunnenberg HG, Clevers H, Kuball J, Sebestyen Z, Rios AC. Dekkers JF, et al. Nat Biotechnol. 2023 Jan;41(1):60-69. doi: 10.1038/s41587-022-01397-w. Epub 2022 Jul 25. Nat Biotechnol. 2023. PMID: 35879361 Free PMC article.
Here we describe a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means of imaging and transcriptomics. We apply BEHAV3D to live-track >150,000 engineered T cells cultured with patient-derived, solid-t …
Here we describe a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means …
Regulatory considerations in oncologic biosimilar drug development.
Macdonald JC, Hartman H, Jacobs IA. Macdonald JC, et al. MAbs. 2015;7(4):653-61. doi: 10.1080/19420862.2015.1040973. MAbs. 2015. PMID: 25961747 Free PMC article. Review.
Applications for proposed biosimilar monoclonal antibodies are being submitted to the regulatory authorities around the world and may increase patient access to key treatment options upon approval. An understanding among stakeholders (e.g., physicians, patients and their c …
Applications for proposed biosimilar monoclonal antibodies are being submitted to the regulatory authorities around the world and may increa …
Identification of enteroviruses along Lake Victoria shoreline - a potential indicator of sewage pollution.
Opere WM, John M, Ombori O, Kiulia NM. Opere WM, et al. Access Microbiol. 2022 Apr 25;4(4):000334. doi: 10.1099/acmi.0.000334. eCollection 2022. Access Microbiol. 2022. PMID: 35812714 Free PMC article.
E n t e r i c v i r u s e s a r e m a i n l y t r a n s m i t t e d b y t h e f a e c a l - o r a l r o u t e a n d h a v e b e e n l i n k e d t o
E n t e r i c v i r u s e s a r e m a i n l y t r a n s m i t t e d b y t
Healthcare Responses to Gender-Based Violence in Timor-Leste: Women Want Empathy, Information and Safety From an Integrated Support System.
Wild K, Young F, de Araujo G, Fernandes A, Gomes L, Kelly L, Taft A. Wild K, et al. J Interpers Violence. 2022 Dec;37(23-24):NP22175-NP22198. doi: 10.1177/08862605211072156. Epub 2022 Mar 18. J Interpers Violence. 2022. PMID: 35301899
Estudu ida nee ezamina informasaun no intervensaun feto sira neebe hetan violensia domestika ka asaltu seksual sira nia hakarak hosi fornesedor saude iha Timor-Leste, nasaun ida neebe ho populasaun rural barak no numeru ne'ebe mak aas tebes hosi violensia hasoru feto. Meto …
Estudu ida nee ezamina informasaun no intervensaun feto sira neebe hetan violensia domestika ka asaltu seksual sira nia hakarak hosi fornese …
Diagnostic kit for rice blight resistance.
Eom JS, Luo D, Atienza-Grande G, Yang J, Ji C, Thi Luu V, Huguet-Tapia JC, Char SN, Liu B, Nguyen H, Schmidt SM, Szurek B, Vera Cruz C, White FF, Oliva R, Yang B, Frommer WB. Eom JS, et al. Nat Biotechnol. 2019 Nov;37(11):1372-1379. doi: 10.1038/s41587-019-0268-y. Epub 2019 Oct 28. Nat Biotechnol. 2019. PMID: 31659338 Free PMC article.
Bacterial transcription activator-like (TAL) effectors bind to effector-binding elements (EBEs) in SWEET gene promoters and induce SWEET genes. EBE variants that cannot be recognized by TAL effectors abrogate induction, causing resistance. ...We also developed CRISPR-Cas9 …
Bacterial transcription activator-like (TAL) effectors bind to effector-binding elements (EBEs) in SWEET gene promoters and induce SWEET gen …
Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results.
Chalkias S, Whatley JL, Eder F, Essink B, Khetan S, Bradley P, Brosz A, McGhee N, Tomassini JE, Chen X, Zhao X, Sutherland A, Shen X, Girard B, Edwards DK, Feng J, Zhou H, Walsh S, Montefiori DC, Baden LR, Miller JM, Das R. Chalkias S, et al. Nat Med. 2023 Sep;29(9):2325-2333. doi: 10.1038/s41591-023-02517-y. Epub 2023 Aug 31. Nat Med. 2023. PMID: 37653342 Free PMC article. Clinical Trial.
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM. De Souza DC, et al. Nat Commun. 2023 Sep 20;14(1):5850. doi: 10.1038/s41467-023-40923-5. Nat Commun. 2023. PMID: 37730674 Free PMC article.
The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis.
Coburn PS, Wiskur BJ, Christy E, Callegan MC. Coburn PS, et al. Invest Ophthalmol Vis Sci. 2012 Nov 1;53(12):7426-31. doi: 10.1167/iovs.12-10661. Invest Ophthalmol Vis Sci. 2012. PMID: 23036996 Free PMC article.
Diabetic and age-matched nondiabetic mice were tail vein-injected with 10(8) CFU of Klebsiella pneumoniae, a common cause of EBE in diabetics. After either 2 or 4 days postinfection, the EBE incidence was assessed by electroretinography, histology, bacterial counts, …
Diabetic and age-matched nondiabetic mice were tail vein-injected with 10(8) CFU of Klebsiella pneumoniae, a common cause of EBE in d …
98 results