DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.
Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Wang GG, Song J.
Ren W, et al.
Nat Commun. 2021 May 3;12(1):2490. doi: 10.1038/s41467-021-22665-4.
Nat Commun. 2021.
PMID: 33941775
Free PMC article.
Engagement of DNMT1(BAH1)-H4K20me3 ensures heterochromatin targeting of DNMT1 and DNA methylation at LINE-1 retrotransposons, and cooperates with the previously reported readout of histone H3 tail modifications (i.e., H3K9me3 and H3 ubiquitylation) by the RFTS domain to al …
Engagement of DNMT1(BAH1)-H4K20me3 ensures heterochromatin targeting of DNMT1 and DNA methylation at LINE-1 retrotransposons, and cooperates …