Human T(H)17 cells engage gasdermin E pores to release IL-1alpha on NLRP3 inflammasome activation.
Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE.
Chao YY, et al.
Nat Immunol. 2023 Feb;24(2):295-308. doi: 10.1038/s41590-022-01386-w. Epub 2023 Jan 5.
Nat Immunol. 2023.
PMID: 36604548
Free PMC article.
This property was restricted to a subset of human helper type 17 T cells with specificity for Candida albicans and regulated by a T cell-intrinsic NLRP3 inflammasome, and its engagement of a proteolytic cascade of successive caspase-8, caspase-3 and GSDME cleavage a …
This property was restricted to a subset of human helper type 17 T cells with specificity for Candida albicans and regulated by a …