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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1973 2
1974 1
1975 8
1976 6
1977 6
1978 10
1979 7
1980 21
1981 29
1982 33
1983 34
1984 41
1985 30
1986 34
1987 44
1988 50
1989 63
1990 43
1991 53
1992 57
1993 105
1994 69
1995 89
1996 96
1997 129
1998 145
1999 161
2000 211
2001 258
2002 318
2003 319
2004 381
2005 474
2006 474
2007 517
2008 605
2009 731
2010 800
2011 834
2012 903
2013 1027
2014 1180
2015 1284
2016 723
2017 521
2018 780
2019 784
2020 939
2021 1019
2022 972
2023 780
2024 113

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16,179 results

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Page 1
The ADAM metalloproteinases.
Edwards DR, Handsley MM, Pennington CJ. Edwards DR, et al. Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008 Aug 15. Mol Aspects Med. 2008. PMID: 18762209 Free PMC article. Review.
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its function is essential for the development of epithelial tissues. Several other ADAMs have important sheddase functions in particular tissue con …
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its fun …
The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology.
Sezin T, Selvakumar B, Scheffold A. Sezin T, et al. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119192. doi: 10.1016/j.bbamcr.2021.119192. Epub 2022 Jan 1. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 34982961 Free article. Review.
This has spurred the interest to modulate ADAM activity therapeutically in immunological diseases. CD4 T helper (Th) cells are the key regulators of adaptive immune responses. ...Here we provide an overview on the major ADAM-10 substrates relevant for CD4 …
This has spurred the interest to modulate ADAM activity therapeutically in immunological diseases. CD4 T helper (Th) cells are …
Necroptosis, ADAM proteases and intestinal (dys)function.
Heib M, Rose-John S, Adam D. Heib M, et al. Int Rev Cell Mol Biol. 2020;353:83-152. doi: 10.1016/bs.ircmb.2020.02.001. Epub 2020 Mar 5. Int Rev Cell Mol Biol. 2020. PMID: 32381179 Review.
Recently, an unexpected connection between necroptosis and members of the a disintegrin and metalloproteinase (ADAM) protease family has been reported. Necroptosis represents an important cell death routine which helps to protect from viral, bacterial, fungal and parasitic …
Recently, an unexpected connection between necroptosis and members of the a disintegrin and metalloproteinase (ADAM) protease family …
Inhibition of MMPs and ADAM/ADAMTS.
Malemud CJ. Malemud CJ. Biochem Pharmacol. 2019 Jul;165:33-40. doi: 10.1016/j.bcp.2019.02.033. Epub 2019 Feb 28. Biochem Pharmacol. 2019. PMID: 30826330 Free PMC article. Review.
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial joints characteristic of rheumatoid arthritis and osteoarthritis. MMP, ADAM and ADAMTS production is greatly increased under the influ …
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial j …
ADAM-17: the enzyme that does it all.
Gooz M. Gooz M. Crit Rev Biochem Mol Biol. 2010 Apr;45(2):146-69. doi: 10.3109/10409231003628015. Crit Rev Biochem Mol Biol. 2010. PMID: 20184396 Free PMC article. Review.
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an indispensible regulator of almost every cellular event from proliferation to migration. The central role …
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM …
ADAM Proteases and Gastrointestinal Function.
Jones JC, Rustagi S, Dempsey PJ. Jones JC, et al. Annu Rev Physiol. 2016;78:243-76. doi: 10.1146/annurev-physiol-021014-071720. Epub 2015 Nov 19. Annu Rev Physiol. 2016. PMID: 26667078 Free PMC article. Review.
., inflammation) and play a central role in coordinating intercellular communication within the local microenvironment. ADAM10 and ADAM17 are the most studied members of the ADAM family in the gastrointestinal tract. ADAMs regulate many cellular processes associated with i …
., inflammation) and play a central role in coordinating intercellular communication within the local microenvironment. ADAM10 and ADAM17 ar …
ADAM-15 disintegrin-like domain structure and function.
Lu D, Scully M, Kakkar V, Lu X. Lu D, et al. Toxins (Basel). 2010 Oct;2(10):2411-27. doi: 10.3390/toxins2102411. Epub 2010 Oct 19. Toxins (Basel). 2010. PMID: 22069559 Free PMC article. Review.
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integ …
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important funct …
Regulation of Fibrotic Processes in the Liver by ADAM Proteases.
Schmidt-Arras D, Rose-John S. Schmidt-Arras D, et al. Cells. 2019 Oct 9;8(10):1226. doi: 10.3390/cells8101226. Cells. 2019. PMID: 31601007 Free PMC article. Review.
ADAM proteases are therefore major regulators of intercellular signalling pathways. In the present review we discuss how ADAM proteases modulate pro- and anti-fibrotic processes and how ADAM proteases might be harnessed therapeutically in the future....
ADAM proteases are therefore major regulators of intercellular signalling pathways. In the present review we discuss how ADAM …
ADAM-15: a metalloprotease that mediates inflammation.
Charrier-Hisamuddin L, Laboisse CL, Merlin D. Charrier-Hisamuddin L, et al. FASEB J. 2008 Mar;22(3):641-53. doi: 10.1096/fj.07-8876rev. Epub 2007 Sep 28. FASEB J. 2008. PMID: 17905725 Review.
More interestingly, the presence of the RGD integrin-binding sequence in the disintegrin domain of ADAM-15 (MDC-15; metargidin) highlighted ADAM-15 as a protein particularly involved in cell-cell interactions. These findings therefore prompted authors to investigate …
More interestingly, the presence of the RGD integrin-binding sequence in the disintegrin domain of ADAM-15 (MDC-15; metargidin) highl …
Metalloproteinases in melanoma.
Moro N, Mauch C, Zigrino P. Moro N, et al. Eur J Cell Biol. 2014 Jan-Feb;93(1-2):23-9. doi: 10.1016/j.ejcb.2014.01.002. Epub 2014 Jan 27. Eur J Cell Biol. 2014. PMID: 24530009 Review.
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