Batch and continuous flow preparation of Hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by Raman spectroscopy. An exploratory study

Sylvain Christiaens; Xavier Vantyghem; Marilena Radoiu; Jean Jacques Vanden Eynde

doi:10.3390/molecules19079986

Batch and continuous flow preparation of Hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real-time monitoring by Raman spectroscopy. An exploratory study

Molecules. 2014 Jul 9;19(7):9986-98. doi: 10.3390/molecules19079986.

Authors

Sylvain Christiaens¹, Xavier Vantyghem², Marilena Radoiu³, Jean Jacques Vanden Eynde⁴

Affiliations

¹ Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. spit06@hotmail.com.
² Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. mxiano@hotmail.com.
³ SAIREM SAS, 12 porte du Grand Lyon, F-01702 Neyron, France. mradoiu@sairem.com.
⁴ Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium. jean-jacques.vandeneynde@ex.umons.ac.

Abstract

Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem's microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dihydropyridines / chemical synthesis
Dihydropyridines / chemistry*
Heating*
Hot Temperature
Microwaves*
Solvents
Spectrum Analysis, Raman* / instrumentation
Spectrum Analysis, Raman* / methods

Substances

Dihydropyridines
Solvents
1,4-dihydropyridine