Abstract
New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines (2a-f) with 4-chlorobenzensulfonyl chloride (1) to yield N-alkyl/aryl-4-chlorobenzenesulfonamide(3af) that was then derivatized by gearing up with ethyl iodide (4), benzyl chloride (5) and 4-chlorobenzyl chloride (6) using sodium hydride as base to initialize the reaction in a polar aprotic solvent (DMF) to synthesize the derivatives, 7a-f, 8af and 9a-f respectively. Structure elucidation was brought about by IR, 1H-NMR and EIMS spectra for all the synthesized molecules which were evaluated for their antibacterial activities and inhibitory potentials for certain enzymes.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / growth & development
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Chymotrypsin / antagonists & inhibitors
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Drug Design*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Lipoxygenase Inhibitors / chemical synthesis
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Lipoxygenase Inhibitors / pharmacology
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Mass Spectrometry
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Molecular Structure
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Proton Magnetic Resonance Spectroscopy
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Serine Proteinase Inhibitors / chemical synthesis
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Serine Proteinase Inhibitors / pharmacology
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis*
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Sulfonamides / pharmacology*
Substances
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Anti-Bacterial Agents
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Enzyme Inhibitors
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Lipoxygenase Inhibitors
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Serine Proteinase Inhibitors
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Sulfonamides
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4-chlorobenzenesulfonamide
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Chymotrypsin
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alpha-chymotrypsin