Doxorubicin-loaded PLGA nanoparticles for the chemotherapy of glioblastoma: Towards the pharmaceutical development.
Maksimenko O, Malinovskaya J, Shipulo E, Osipova N, Razzhivina V, Arantseva D, Yarovaya O, Mostovaya U, Khalansky A, Fedoseeva V, Alekseeva A, Vanchugova L, Gorshkova M, Kovalenko E, Balabanyan V, Melnikov P, Baklaushev V, Chekhonin V, Kreuter J, Gelperina S.
Maksimenko O, et al.
Int J Pharm. 2019 Dec 15;572:118733. doi: 10.1016/j.ijpharm.2019.118733. Epub 2019 Nov 2.
Int J Pharm. 2019.
PMID: 31689481
The pilot scale process was characterized by an excellent reproducibility with very low inter-batch variations. The in vitro hematotoxicity of the nanoparticles was negligible at therapeutically relevant concentrations. ...
The pilot scale process was characterized by an excellent reproducibility with very low inter-batch variations. The in vitro hematoto …