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Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells.
Dos Santos DF, de Pilger DRB, Vandermeulen C, Khouri R, Mantoani SP, Nunes PSG, de Andrade P, Carvalho I, Casseb J, Twizere JC, Willems L, Freitas-Junior L, Kashima S. Dos Santos DF, et al. Bioorg Med Chem. 2020 Nov 15;28(22):115746. doi: 10.1016/j.bmc.2020.115746. Epub 2020 Sep 8. Bioorg Med Chem. 2020. PMID: 33007558
CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties.
Zamoner LO, Aragão-Leoneti V, Mantoani SP, Rugen MD, Nepogodiev SA, Field RA, Carvalho I. Zamoner LO, et al. Among authors: mantoani sp. Carbohydr Res. 2016 Jun 24;429:29-37. doi: 10.1016/j.carres.2016.04.020. Epub 2016 Apr 22. Carbohydr Res. 2016. PMID: 27160849