Abstract
Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology
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Ascomycota / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Fermentation
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Mycelium / chemistry
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Naphthalenes / isolation & purification
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Naphthalenes / metabolism*
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Naphthalenes / pharmacology*
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Rhizophoraceae / microbiology*
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Spectrophotometry, Ultraviolet
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X-Ray Diffraction
Substances
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Antibiotics, Antineoplastic
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Naphthalenes