An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in Aqueous Media

Suh Mi Hwang; Dongju Yun; Cheal Kim

doi:10.1007/s10895-019-02355-7

An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in Aqueous Media

J Fluoresc. 2019 Mar;29(2):451-459. doi: 10.1007/s10895-019-02355-7. Epub 2019 Feb 2.

Authors

Suh Mi Hwang¹, Dongju Yun¹, Cheal Kim²

Affiliations

¹ Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, 129-743, South Korea.
² Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, 129-743, South Korea. chealkim@seoultech.ac.kr.

PMID: 30710188
DOI: 10.1007/s10895-019-02355-7

Abstract

A new fluorometric chemodosimeter 2-amino-3-(((E)-3-(1-phenylimidazo[1,5-α]pyridin-3-yl)benzylidene)amino)maleonitrile (BPI-MAL) has been designed and synthesized for sensing hypochlorite. BPI-MAL showed a selective turn-on fluorescence for ClO^- through hypochlorite-promoted de-diaminomaleonitrile reaction. It also could detect ClO^- in the presence of various competitive anions including reactive oxygen species. Interestingly, sensor BPI-MAL was successfully applied as a fluorescent test kit for ClO^- determination. The sensing property and mechanism of BPI-MAL toward ClO^- were studied by fluorescence and UV-vis spectroscopy, NMR titration and DFT calculations.

Keywords: Fluorescent chemodosimeter; Hypochlorite; Imidazo[1,5-a]pyridine; Test kit; Theoretical calculations.

Abstract

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