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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
As compared with placebo, the effects of pemafibrate on lipid levels at 4 months were -26.2% for triglycerides, -25.8% for very-low-density lipoprotein (VLDL) cholesterol, -25.6% for remnant cholesterol (cholesterol transported in triglyceride-rich lipoproteins after lipolysis an …
As compared with placebo, the effects of pemafibrate on lipid levels at 4 months were -26.2% for triglycerides, -25.8% for very-low-density …
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Pagano G, Boess FG, Taylor KI, Ricci B, Mollenhauer B, Poewe W, Boulay A, Anzures-Cabrera J, Vogt A, Marchesi M, Post A, Nikolcheva T, Kinney GG, Zago WM, Ness DK, Svoboda H, Britschgi M, Ostrowitzki S, Simuni T, Marek K, Koller M, Sevigny J, Doody R, Fontoura P, Umbricht D, Bonni A; PASADENA Investigators; Prasinezumab Study Group. Pagano G, et al. Front Neurol. 2021 Oct 1;12:705407. doi: 10.3389/fneur.2021.705407. eCollection 2021. Front Neurol. 2021. PMID: 34659081 Free PMC article.
., resting tremor, rigidity); DAT-SPECT imaging consistent with PD; and either treatment naive or on a stable monoamine oxidase B (MAO-B) inhibitor dose. Study design assumptions for sample size and study duration were built using a patient cohort from the Parkinson …
., resting tremor, rigidity); DAT-SPECT imaging consistent with PD; and either treatment naive or on a stable monoamine oxidase B (MA …
When is it Safe to Drive After Total Ankle Arthroplasty?
McDonald EL, Pedowitz DI, Shakked RJ, Fuchs DJ, Winters BS, Daniel JN, Raikin SM. McDonald EL, et al. Clin Orthop Relat Res. 2020 Jan;478(1):8-15. doi: 10.1097/CORR.0000000000000881. Clin Orthop Relat Res. 2020. PMID: 31425279 Free PMC article.
Molecular characterization of influenza viruses from women and infants in Sarlahi, Nepal.
Kuypers J, Chu HY, Gaydos CA, Katz J, Khatry SK, LeClerq SC, Tielsch JM, Steinhoff MC, Englund JA. Kuypers J, et al. Diagn Microbiol Infect Dis. 2019 Apr;93(4):305-310. doi: 10.1016/j.diagmicrobio.2018.11.004. Epub 2018 Nov 15. Diagn Microbiol Infect Dis. 2019. PMID: 30528424 Free PMC article.
A(H3N2) strains with less than 13 aa differences in HA compared to vaccine strains (matched) showed higher VE than strains with 13 or more differences (mismatched). Yamagata lineage B strains, which were mismatched to the Victoria strain in the vaccine, demonstrated lower …
A(H3N2) strains with less than 13 aa differences in HA compared to vaccine strains (matched) showed higher VE than strains with 13 or more d …
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.
Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J. Swamynathan SK, et al. Mol Cell Biol. 2007 Jan;27(1):182-94. doi: 10.1128/MCB.00846-06. Epub 2006 Oct 23. Mol Cell Biol. 2007. PMID: 17060454 Free PMC article.
The Kruppel-like transcription factor KLF4 is among the most highly expressed transcription factors in the mouse cornea (B. Norman, J. Davis, and J. Piatigorsky, Investig. Ophthalmol. ...Here, we deleted the Klf4 gene selectively in the surface ectoderm-derived structures …
The Kruppel-like transcription factor KLF4 is among the most highly expressed transcription factors in the mouse cornea (B. Norman, J …
Assessment of indirect protection from maternal influenza immunization among non-vaccinated household family members in a randomized controlled trial in Sarlahi, Nepal.
Newman KL, Stewart LM, Scott EM, Tielsch JM, Englund JA, Khatry SK, Mullany LC, LeClerq SC, Shrestha L, Kuypers JM, Chu HY, Katz J. Newman KL, et al. Vaccine. 2020 Oct 7;38(43):6826-6831. doi: 10.1016/j.vaccine.2020.08.014. Epub 2020 Aug 17. Vaccine. 2020. PMID: 32814640 Free PMC article. Clinical Trial.
Of the influenza strains able to be typed, 29 were influenza A, 40 were influenza B, and 6 were coinfections with influenza A and B. The rate did not differ significantly whether the household was in the vaccine or placebo group (rate ratio (RR) 1.37, 95% confidence …
Of the influenza strains able to be typed, 29 were influenza A, 40 were influenza B, and 6 were coinfections with influenza A and …
Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites.
Habeck M, Haviv H, Katz A, Kapri-Pardes E, Ayciriex S, Shevchenko A, Ogawa H, Toyoshima C, Karlish SJD. Habeck M, et al. J Biol Chem. 2015 Feb 20;290(8):4829-4842. doi: 10.1074/jbc.M114.611384. Epub 2014 Dec 22. J Biol Chem. 2015. PMID: 25533463 Free PMC article.
We show here that cholesterol associates with SOPS, FXYD1, and the alpha subunit between trans-membrane segments alphaTM8 and -10 to stabilize the protein. (b) Polyunsaturated neutral lipids stimulate Na,K-ATPase turnover by >60%. ...
We show here that cholesterol associates with SOPS, FXYD1, and the alpha subunit between trans-membrane segments alphaTM8 and -10 to stabili …