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Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67.
Alshammari AM, Smith DD, Parriott J, Stewart JP, Curran SM, McCulloh RJ, Barry PA, Iyer SS, Palermo N, Phillips JA, Dong Y, Ronning DR, Vennerstrom JL, Sanderson SD, Vetro JA. Alshammari AM, et al. Among authors: curran sm. ACS Infect Dis. 2020 May 8;6(5):1169-1181. doi: 10.1021/acsinfecdis.0c00005. Epub 2020 Apr 13. ACS Infect Dis. 2020. PMID: 32233506 Free PMC article.
Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization.
Parriott JE, Stewart JP, Smith DD, Curran SM, Bauer CD, Wyatt TA, Phillips JA, Lyden E, Thiele GM, Vetro JA. Parriott JE, et al. Among authors: curran sm. Pharmaceutics. 2022 Sep 1;14(9):1843. doi: 10.3390/pharmaceutics14091843. Pharmaceutics. 2022. PMID: 36145590 Free PMC article.
Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection.
Tallapaka SB, Karuturi BVK, Yeapuri P, Curran SM, Sonawane YA, Phillips JA, David Smith D, Sanderson SD, Vetro JA. Tallapaka SB, et al. Among authors: curran sm. Int J Pharm. 2019 Jun 30;565:242-257. doi: 10.1016/j.ijpharm.2019.05.012. Epub 2019 May 8. Int J Pharm. 2019. PMID: 31077762 Free PMC article.
Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration.
Ambardekar VV, Wakaskar RR, Ye Z, Curran SM, McGuire TR, Coulter DW, Singh RK, Vetro JA. Ambardekar VV, et al. Among authors: curran sm. Int J Pharm. 2018 May 30;543(1-2):130-138. doi: 10.1016/j.ijpharm.2018.03.045. Epub 2018 Mar 27. Int J Pharm. 2018. PMID: 29601972 Free PMC article.
Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a Diameter-Dependent Manner.
Karuturi BVK, Tallapaka SB, Yeapuri P, Curran SM, Sanderson SD, Vetro JA. Karuturi BVK, et al. Among authors: curran sm. Mol Pharm. 2017 May 1;14(5):1469-1481. doi: 10.1021/acs.molpharmaceut.6b01088. Epub 2017 Apr 3. Mol Pharm. 2017. PMID: 28319404 Free PMC article.
Peripherally cross-linking the shell of core-shell polymer micelles decreases premature release of physically loaded combretastatin A4 in whole blood and increases its mean residence time and subsequent potency against primary murine breast tumors after IV administration.
Wakaskar RR, Bathena SP, Tallapaka SB, Ambardekar VV, Gautam N, Thakare R, Simet SM, Curran SM, Singh RK, Dong Y, Vetro JA. Wakaskar RR, et al. Among authors: curran sm. Pharm Res. 2015 Mar;32(3):1028-44. doi: 10.1007/s11095-014-1515-z. Epub 2014 Sep 16. Pharm Res. 2015. PMID: 25223962 Free PMC article.