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Page 1
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.
NPJ Precis Oncol. 2023 Dec 15;7(1):136. doi: 10.1038/s41698-023-00486-6.
NPJ Precis Oncol. 2023.
PMID: 38102334
Free PMC article.
Epigenetic effects of metformin: From molecular mechanisms to clinical implications.
Bridgeman SC, Ellison GC, Melton PE, Newsholme P, Mamotte CDS.
Bridgeman SC, et al.
Diabetes Obes Metab. 2018 Jul;20(7):1553-1562. doi: 10.1111/dom.13262. Epub 2018 Mar 22.
Diabetes Obes Metab. 2018.
PMID: 29457866
Review.
Item in Clipboard
Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome.
Bridgeman SC, Northrop W, Melton PE, Ellison GC, Newsholme P, Mamotte CDS.
Bridgeman SC, et al.
Pharmacol Res. 2020 Oct;160:105174. doi: 10.1016/j.phrs.2020.105174. Epub 2020 Aug 27.
Pharmacol Res. 2020.
PMID: 32860943
Review.
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Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling.
Bridgeman S, Woo HC, Newsholme P, Mamotte C.
Bridgeman S, et al.
Int J Mol Sci. 2022 Dec 7;23(24):15506. doi: 10.3390/ijms232415506.
Int J Mol Sci. 2022.
PMID: 36555149
Free PMC article.
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High-fat diet induced alterations in plasma membrane cholesterol content impairs insulin receptor binding and signalling in mouse liver but is ameliorated by atorvastatin.
Sabapathy T, Helmerhorst E, Ellison G, Bridgeman SC, Mamotte CD.
Sabapathy T, et al. Among authors: bridgeman sc.
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 1;1868(6):166372. doi: 10.1016/j.bbadis.2022.166372. Epub 2022 Mar 4.
Biochim Biophys Acta Mol Basis Dis. 2022.
PMID: 35248691
Free article.
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The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I.
Bridgeman S, Ellison G, Newsholme P, Mamotte C.
Bridgeman S, et al.
Int J Mol Sci. 2021 Dec 11;22(24):13330. doi: 10.3390/ijms222413330.
Int J Mol Sci. 2021.
PMID: 34948127
Free PMC article.
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Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes.
Bridgeman S, Northrop W, Ellison G, Sabapathy T, Melton PE, Newsholme P, Mamotte CDS.
Bridgeman S, et al.
Cancers (Basel). 2019 Apr 10;11(4):516. doi: 10.3390/cancers11040516.
Cancers (Basel). 2019.
PMID: 30974899
Free PMC article.
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