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Showing results for stefania scaling
Search for Stefania Scalingi instead (2 results)
Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids.
Costamagna G, Comi GP, Corti S. Costamagna G, et al. Int J Mol Sci. 2021 Mar 6;22(5):2659. doi: 10.3390/ijms22052659. Int J Mol Sci. 2021. PMID: 33800815 Free PMC article. Review.
Their use to model brain biology, early neural development, and human diseases has provided new insights into the pathophysiology of neuropsychiatric and neurological disorders, including microcephaly, autism, Parkinson's disease, and Alzheimer's disease. However, the adoption of …
Their use to model brain biology, early neural development, and human diseases has provided new insights into the pathophysiology of neurops …
Cannabidiol (CBD) use in psychiatric disorders: A systematic review.
Bonaccorso S, Ricciardi A, Zangani C, Chiappini S, Schifano F. Bonaccorso S, et al. Neurotoxicology. 2019 Sep;74:282-298. doi: 10.1016/j.neuro.2019.08.002. Epub 2019 Aug 11. Neurotoxicology. 2019. PMID: 31412258 Review.
However, available trials reported potential therapeutic effects for specific psychopathological conditions, such as substance use disorders, chronic psychosis, and anxiety. Further large-scale RCTs are required to better evaluate the efficacy of CBD in both acute and chro …
However, available trials reported potential therapeutic effects for specific psychopathological conditions, such as substance use disorders …
Role of monomeric amyloid-β in cognitive performance in Alzheimer's disease: Insights from clinical trials with secretase inhibitors and monoclonal antibodies.
Imbimbo BP, Ippati S, Watling M, Imbimbo C. Imbimbo BP, et al. Pharmacol Res. 2023 Jan;187:106631. doi: 10.1016/j.phrs.2022.106631. Epub 2022 Dec 28. Pharmacol Res. 2023. PMID: 36586644 Free article. Review.
Numerous anti-Abeta drugs either inhibiting production or aggregation of Abeta or stimulating its clearance have failed to show clinical benefit in large scale AD trials, with beta- and gamma-secretase inhibitors consistently worsening cognitive and clinical decline. ...
Numerous anti-Abeta drugs either inhibiting production or aggregation of Abeta or stimulating its clearance have failed to show clinical ben …
Spatial metatranscriptomics resolves host-bacteria-fungi interactomes.
Saarenpää S, Shalev O, Ashkenazy H, Carlos V, Lundberg DS, Weigel D, Giacomello S. Saarenpää S, et al. Nat Biotechnol. 2023 Nov 20. doi: 10.1038/s41587-023-01979-2. Online ahead of print. Nat Biotechnol. 2023. PMID: 37985875
We showcase SmT in outdoor-grown Arabidopsis thaliana leaves as a model system, and find tissue-scale bacterial and fungal hotspots. By network analysis, we study inter- and intrakingdom spatial interactions among microorganisms, as well as the host response to microbial h …
We showcase SmT in outdoor-grown Arabidopsis thaliana leaves as a model system, and find tissue-scale bacterial and fungal hotspots. …
Tauro-Urso-Deoxycholic Acid Trials in Amyotrophic Lateral Sclerosis: What is Achieved and What to Expect.
Lo Giudice M, Cocco A, Reggiardo G, Lalli S, Albanese A. Lo Giudice M, et al. Clin Drug Investig. 2023 Dec;43(12):893-903. doi: 10.1007/s40261-023-01324-0. Epub 2023 Nov 16. Clin Drug Investig. 2023. PMID: 37973672 Free PMC article. Review.
Two independent phase II studies (using TUDCA solo or combined with sodium phenylbutyrate) showed similar efficacy in slowing disease progression measured by functional scales. One open-label follow-up TUDCA+sodium phenylbutyrate study suggested a benefit on survival. ...
Two independent phase II studies (using TUDCA solo or combined with sodium phenylbutyrate) showed similar efficacy in slowing disease progre …
The burden of the knowledge-to-action gap in acute appendicitis.
Cioffi SPB, Altomare M, Podda M, Spota A, Granieri S, Reitano E, Zamburlini B, Virdis F, Bini R, Gupta S, Torzilli G, Mingoli A, Chiara O, Cimbanassi S; REsiDENT-1 research group. Cioffi SPB, et al. Surg Endosc. 2023 Dec;37(12):9617-9632. doi: 10.1007/s00464-023-10449-4. Epub 2023 Oct 26. Surg Endosc. 2023. PMID: 37884735 Free PMC article.
We applied our classification proposal and used a five-point Likert scale (Ls) to assess laparoscopic appendectomy (LA) difficulty. Descriptive analyses were performed to explore compliance and group comparisons to assess the impact on outcomes and related costs. ...
We applied our classification proposal and used a five-point Likert scale (Ls) to assess laparoscopic appendectomy (LA) difficulty. D …
Impact of pembrolizumab versus chemotherapy on health-related quality of life in patients with metastatic triple-negative breast cancer: results from the phase 3 randomised KEYNOTE-119 study.
Schmid P, Lipatov O, Im SA, Goncalves A, Muñoz-Couselo E, Lee KS, Tamura K, Testa L, Witzel I, Ohtani S, Turner N, Zambelli S, Harbeck N, Andre F, Dent R, Mejia JA, Zhou X, Haiderali A, Nguyen AM, Cortes J, Winer EP. Schmid P, et al. Eur J Cancer. 2023 Dec;195:113393. doi: 10.1016/j.ejca.2023.113393. Epub 2023 Oct 21. Eur J Cancer. 2023. PMID: 37976633 Clinical Trial.
Changes from baseline at 6 weeks (primary analysis time point) were directionally better with pembrolizumab versus chemotherapy for QLQ-C30 GHS/QoL (between-group difference in least-squares mean scores of 4.21 [95% CI, -1.38 to 9.80]), QLQ-C30 functional scales (physical, …
Changes from baseline at 6 weeks (primary analysis time point) were directionally better with pembrolizumab versus chemotherapy for QLQ-C30 …
Enabling automated and reproducible spatially resolved transcriptomics at scale.
Stenbeck L, Taborsak-Lines F, Giacomello S. Stenbeck L, et al. Heliyon. 2022 Jun 11;8(6):e09651. doi: 10.1016/j.heliyon.2022.e09651. eCollection 2022 Jun. Heliyon. 2022. PMID: 35756107 Free PMC article.
Our automated Visium library preparation protocol provides a new strategy to standardize spatially resolved transcriptomics analysis of tissues at scale....
Our automated Visium library preparation protocol provides a new strategy to standardize spatially resolved transcriptomics analysis of tiss …
One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation.
Del Prete S, Mikulski P, Schubert D, Gaudin V. Del Prete S, et al. Genes (Basel). 2015 Jul 10;6(3):520-42. doi: 10.3390/genes6030520. Genes (Basel). 2015. PMID: 26184319 Free PMC article. Review.
PcG proteins contribute to a multitude of biological processes by altering chromatin features at different scales. PcG proteins mediate both biochemical modifications of histone tails and biophysical modifications (e.g., chromatin fiber compaction and three-dimensional (3D …
PcG proteins contribute to a multitude of biological processes by altering chromatin features at different scales. PcG proteins media …
Multi-Dimensional Dyspnea-Related Scales Validated in Individuals With Cardio-Respiratory and Cancer Diseases. A Systematic Review of Psychometric Properties.
Tinti S, Parati M, De Maria B, Urbano N, Sardo V, Falcone G, Terzoni S, Alberti A, Destrebecq A. Tinti S, et al. J Pain Symptom Manage. 2022 Jan;63(1):e46-e58. doi: 10.1016/j.jpainsymman.2021.07.011. Epub 2021 Aug 3. J Pain Symptom Manage. 2022. PMID: 34358643 Review.
Although the use of these scales has rapidly grown, evidence of psychometric properties has been reported as limited in most of the scales. CONCLUSION: Despite the potential of the identified scales, further studies are needed to strength evidence on the vali …
Although the use of these scales has rapidly grown, evidence of psychometric properties has been reported as limited in most of the …
109 results