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Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.
Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG. Delfinis LJ, et al. Among authors: tsitkanou s. JCI Insight. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147. JCI Insight. 2022. PMID: 36346680 Free PMC article.
Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia.
Cabrera AR, Deaver JW, Lim S, Morena da Silva F, Schrems ER, Saling LW, Tsitkanou S, Rosa-Caldwell ME, Wiggs MP, Washington TA, Greene NP. Cabrera AR, et al. Among authors: tsitkanou s. J Appl Physiol (1985). 2023 Sep 1;135(3):655-672. doi: 10.1152/japplphysiol.00196.2023. Epub 2023 Aug 3. J Appl Physiol (1985). 2023. PMID: 37535708