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The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
Avrova SV, Karpicheva OE, Rysev NA, Simonyan AO, Sirenko VV, Redwood CS, Borovikov YS. Avrova SV, et al. Biochem Biophys Res Commun. 2018 Jul 12;502(2):209-214. doi: 10.1016/j.bbrc.2018.05.145. Epub 2018 May 26. Biochem Biophys Res Commun. 2018. PMID: 29792862
The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
Borovikov YS, Simonyan AO, Karpicheva OE, Avrova SV, Rysev NA, Sirenko VV, Piers A, Redwood CS. Borovikov YS, et al. Among authors: avrova sv. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):681-686. doi: 10.1016/j.bbrc.2017.10.161. Epub 2017 Oct 31. Biochem Biophys Res Commun. 2017. PMID: 29097206
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