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PNUTS functions as a proto-oncogene by sequestering PTEN.
Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. Kavela S, et al. Cancer Res. 2013 Jan 1;73(1):205-14. doi: 10.1158/0008-5472.CAN-12-1394. Epub 2012 Nov 1. Cancer Res. 2013. PMID: 23117887 Free PMC article.
WWP2 is an E3 ubiquitin ligase for PTEN.
Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. Maddika S, et al. Among authors: kavela s. Nat Cell Biol. 2011 Jun;13(6):728-33. doi: 10.1038/ncb2240. Epub 2011 May 1. Nat Cell Biol. 2011. PMID: 21532586 Free PMC article.
TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S. Shinde SR, et al. Among authors: kavela s. Cell Signal. 2013 Dec;25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3. Cell Signal. 2013. PMID: 24012691 Free PMC article.