Structure-Function Relationship in Patients with Retinitis Pigmentosa and Hyperautofluorescent Rings

This study aimed to investigate the association between retinal sensitivity and retinal microstructures in fundus autofluorescence (FAF) and optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP) and hyperautofluorescent (hyperAF) rings. This cross-sectional study included 44 eyes from 26 consecutive patients with RP. The morphological geometry of the hyperAF ring, such as three distinct FAF regions, hyperAF ring area, and longest diameter of the hyperAF ring on FAF, and the retinal microstructure, such as total retinal thickness (TRT) and outer retinal thickness (ORT), on OCT, were evaluated. A strong correlation of mean retinal sensitivity with hyperAF ring area (R = 0.8013, p < 0.001) and longest diameter of the hyperAF ring (R = 0.9072, p < 0.001) was observed. Segmented linear regression (SLR) analysis revealed breakpoints of 12.83 mm² and 5.21 mm, respectively. ORT (R = 0.6551, p < 0.001) was more strongly correlated with retinal sensitivity than TRT (R = 0.2732, p < 0.001). SLR analysis revealed a breakpoint between the ORT and retinal sensitivity of 145.12 μm. In patients with RP and hyperAF rings, retinal sensitivity was strongly associated with the morphological geometry of the hyperAF ring. ORT, rather than TRT, strongly correlated with retinal sensitivity.