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Page 1
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit.
Singleton DC, Mowday AM, Guise CP, Syddall SP, Bai SY, Li D, Ashoorzadeh A, Smaill JB, Wilson WR, Patterson AV. Singleton DC, et al. Among authors: syddall sp. Cancer Gene Ther. 2022 Jul;29(7):1021-1032. doi: 10.1038/s41417-021-00409-2. Epub 2021 Nov 26. Cancer Gene Ther. 2022. PMID: 34837065
E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.
Mowday AM, Copp JN, Syddall SP, Dubois LJ, Wang J, Lieuwes NG, Biemans R, Ashoorzadeh A, Abbattista MR, Williams EM, Guise CP, Lambin P, Ackerley DF, Smaill JB, Theys J, Patterson AV. Mowday AM, et al. Among authors: syddall sp. Theranostics. 2020 Aug 21;10(23):10548-10562. doi: 10.7150/thno.46826. eCollection 2020. Theranostics. 2020. PMID: 32929365 Free PMC article.
Hemoglobin Levels Across the Pediatric Critical Care Spectrum: A Point Prevalence Study.
Hassan NE, Reischman DE, Fitzgerald RK, Faustino EVS; Prophylaxis Against Thrombosis Practice (PROTRACT) Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)/BloodNet Investigators. Hassan NE, et al. Pediatr Crit Care Med. 2018 May;19(5):e227-e234. doi: 10.1097/PCC.0000000000001467. Pediatr Crit Care Med. 2018. PMID: 29384892
[Thromboprophylaxis in critically ill children in Spain and Portugal].
Rodríguez Núñez A, Fonte M, Faustino EV; investigadores del estudio multicéntrico internacional PROTRACT. Rodríguez Núñez A, et al. An Pediatr (Barc). 2015 Mar;82(3):144-51. doi: 10.1016/j.anpedi.2014.05.001. Epub 2014 Jun 5. An Pediatr (Barc). 2015. PMID: 24907863 Free PMC article.
Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.
Prosser GA, Copp JN, Mowday AM, Guise CP, Syddall SP, Williams EM, Horvat CN, Swe PM, Ashoorzadeh A, Denny WA, Smaill JB, Patterson AV, Ackerley DF. Prosser GA, et al. Among authors: syddall sp. Biochem Pharmacol. 2013 Apr 15;85(8):1091-103. doi: 10.1016/j.bcp.2013.01.029. Epub 2013 Feb 8. Biochem Pharmacol. 2013. PMID: 23399641