Abstract
Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.
MeSH terms
-
Acetamides / chemistry
-
Anti-Bacterial Agents / pharmacology*
-
Chemistry, Pharmaceutical / methods*
-
Drug Design
-
Drug Resistance, Bacterial
-
Gram-Negative Bacteria
-
Linezolid
-
Mass Spectrometry
-
Methicillin / pharmacology
-
Microbial Sensitivity Tests*
-
Models, Chemical
-
Oxazolidinones / chemistry*
-
Piperazine
-
Piperazines / chemistry
-
Sulfur / chemistry*
-
Temperature
-
Thiocarbamates / chemistry
Substances
-
Acetamides
-
Anti-Bacterial Agents
-
Oxazolidinones
-
Piperazines
-
Thiocarbamates
-
Piperazine
-
Sulfur
-
Linezolid
-
Methicillin