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Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem - evaluated by microdialysis in a porcine model : should patients with open fractures have higher doses of antibiotics?
Vittrup SØ, Hanberg P, Knudsen MB, Tøstesen SK, Kipp JO, Hansen J, Jørgensen NP, Stilling M, Bue M. Vittrup SØ, et al. Bone Joint Res. 2022 Feb;11(2):112-120. doi: 10.1302/2046-3758.112.BJR-2021-0321.R1. Bone Joint Res. 2022. PMID: 35176868 Free PMC article.
Rifampicin does not reduce moxifloxacin concentrations at the site of infection and may not improve treatment outcome of a one-stage exchange surgery protocol of implant-associated osteomyelitis lesions in a porcine model.
Vittrup S, Jensen LK, Hartmann KT, Aalbaek B, Hanberg P, Slater J, Hvistendahl MA, Stilling M, Jørgensen NP, Bue M. Vittrup S, et al. APMIS. 2024 Mar;132(3):198-209. doi: 10.1111/apm.13371. Epub 2023 Dec 28. APMIS. 2024. PMID: 38153297