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Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction.
Giacosa S, Pillet C, Séraudie I, Guyon L, Wallez Y, Roelants C, Battail C, Evrard B, Chalmel F, Barette C, Soleilhac E, Fauvarque MO, Franquet Q, Sarrazin C, Peilleron N, Fiard G, Long JA, Descotes JL, Cochet C, Filhol O. Giacosa S, et al. Cancers (Basel). 2021 Feb 2;13(3):576. doi: 10.3390/cancers13030576. Cancers (Basel). 2021. PMID: 33540838 Free PMC article.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. Sebastián C, et al. Among authors: giacosa s. Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047. Cell. 2012. PMID: 23217706 Free PMC article.
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. Toiber D, et al. Among authors: giacosa s. Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1. Mol Cell. 2013. PMID: 23911928 Free PMC article.