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The following term was not found in PubMed: Eskela-Haapanen
Page 1
The CD47-SIRPα Immune Checkpoint.
Logtenberg MEW, Scheeren FA, Schumacher TN. Logtenberg MEW, et al. Immunity. 2020 May 19;52(5):742-752. doi: 10.1016/j.immuni.2020.04.011. Immunity. 2020. PMID: 32433947 Free PMC article. Review.
Dendritic cell subsets and locations.
Balan S, Saxena M, Bhardwaj N. Balan S, et al. Int Rev Cell Mol Biol. 2019;348:1-68. doi: 10.1016/bs.ircmb.2019.07.004. Epub 2019 Sep 3. Int Rev Cell Mol Biol. 2019. PMID: 31810551 Review.
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma.
Zhou Z, Chen MM, Luo Y, Mojumdar K, Peng X, Chen H, Kumar SV, Akbani R, Lu Y, Liang H. Zhou Z, et al. Cancer Cell. 2022 Nov 14;40(11):1324-1340.e8. doi: 10.1016/j.ccell.2022.10.012. Epub 2022 Nov 3. Cancer Cell. 2022. PMID: 36332624 Free PMC article.
Mice bearing SIRPA-deficient melanoma tumors show no response to anti-PD-L1 treatment, whereas melanoma-specific SIRPA overexpression significantly enhances immunotherapy response. Mechanistically, SIRPA is regulated by its pseudogene, SIRPAP1. Our results su …
Mice bearing SIRPA-deficient melanoma tumors show no response to anti-PD-L1 treatment, whereas melanoma-specific SIRPA overexp …
Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis.
Zhang W, Huang Q, Xiao W, Zhao Y, Pi J, Xu H, Zhao H, Xu J, Evans CE, Jin H. Zhang W, et al. Front Immunol. 2020 Jan 28;11:18. doi: 10.3389/fimmu.2020.00018. eCollection 2020. Front Immunol. 2020. PMID: 32082311 Free PMC article. Review.
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Morrissey MA, Kern N, Vale RD. Morrissey MA, et al. Immunity. 2020 Aug 18;53(2):290-302.e6. doi: 10.1016/j.immuni.2020.07.008. Epub 2020 Aug 7. Immunity. 2020. PMID: 32768386 Free PMC article.
Here, we utilized a reconstituted system with a defined set of signals to interrogate the mechanism of SIRPA activation and its downstream targets. CD47 ligation altered SIRPA localization, positioning SIRPA for activation at the phagocytic synapse. At the ph …
Here, we utilized a reconstituted system with a defined set of signals to interrogate the mechanism of SIRPA activation and its downs …
CD47: role in the immune system and application to cancer therapy.
Hayat SMG, Bianconi V, Pirro M, Jaafari MR, Hatamipour M, Sahebkar A. Hayat SMG, et al. Cell Oncol (Dordr). 2020 Feb;43(1):19-30. doi: 10.1007/s13402-019-00469-5. Epub 2019 Aug 14. Cell Oncol (Dordr). 2020. PMID: 31485984 Review.
SIRPA enhances osteosarcoma metastasis by stabilizing SP1 and promoting SLC7A3-mediated arginine uptake.
Wang P, Song Y, Li H, Zhuang J, Shen X, Yang W, Mi R, Lu Y, Yang B, Ma M, Shen H. Wang P, et al. Cancer Lett. 2023 Nov 1;576:216412. doi: 10.1016/j.canlet.2023.216412. Epub 2023 Sep 26. Cancer Lett. 2023. PMID: 37769797
The function of signal regulatory protein alpha (SIRPA) has been well studied in macrophages and dendritic cells, but relatively less in tumors. ...Knockdown of SIRPA impaired OS cell migration by decreasing specificity protein 1 (SP1) stability and arginine uptake. …
The function of signal regulatory protein alpha (SIRPA) has been well studied in macrophages and dendritic cells, but relatively less …
665 results