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Did you mean sirna lei (773 results)?
Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes.
Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY. Qiu Z, et al. J Diabetes Res. 2019 Feb 17;2019:8151836. doi: 10.1155/2019/8151836. eCollection 2019. J Diabetes Res. 2019. PMID: 30911553 Free PMC article.
H9C2 cardiomyocytes were exposed to HG (30 mM) condition with or without LPS, along with caspase-1 inhibitor (Ac-YVAD-CMK), inflammasome inhibitor (BAY11-7082), ROS scavenger N-acetylcysteine (NAC), or not for 24 h, then subjected to 4 h of hypoxia followed by 2 h of reoxy …
H9C2 cardiomyocytes were exposed to HG (30 mM) condition with or without LPS, along with caspase-1 inhibitor (Ac-YVAD-CMK), inflammasome inh …
Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis.
Yang D, Zhu J, Zhou X, Pan D, Nan S, Yin R, Lei Q, Ma N, Zhu H, Chen J, Han L, Ding M, Ding Y. Yang D, et al. Environ Int. 2022 Aug;166:107362. doi: 10.1016/j.envint.2022.107362. Epub 2022 Jun 18. Environ Int. 2022. PMID: 35749991 Free article.
Maternal administration of PS particles during gestation led to anxiety-like behavior of the progenies and their gamma-aminobutyric acid (GABA) reduction in the prefrontal cortex and amygdala at Week 8. N-Acetylcysteine (NAC), an antioxidant, alleviated PS particles-induce …
Maternal administration of PS particles during gestation led to anxiety-like behavior of the progenies and their gamma-aminobutyric acid (GA …
Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.
Fang Z, Xu Y, Liu G, Shao Q, Niu X, Tai W, Shen T, Fan M, Chen M, Lei L, Gao W, Song Y, Wang Z, Du X, Li X. Fang Z, et al. Autophagy. 2023 Aug;19(8):2240-2256. doi: 10.1080/15548627.2023.2179781. Epub 2023 Feb 24. Autophagy. 2023. PMID: 36779633 Free PMC article.
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential agent for treating APAP overdose.Abbreviations: ALP: autophagy-lysosomal pathway; APAP: acetaminophen; APAP-AD: APAP-protein adducts; APAP-Cys: …
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential age …
Inflammation Intensifies Monocrotaline-Induced Liver Injury.
Gong B, Zhang S, Wang X, Ran G, Zhang X, Xi J, Gao Z, Lei Y, Pan J, Liu Y, Luan Y, Zhang X, Peng Y, Li W, Zheng J. Gong B, et al. J Agric Food Chem. 2023 Feb 8. doi: 10.1021/acs.jafc.2c07939. Online ahead of print. J Agric Food Chem. 2023. PMID: 36753335
N-Chloromonocrotaline was detected in both HClO/MCT incubations and MPO/H(2)O(2)/MgCl(2)/MCT incubations. DHM-derived N-acetylcysteine (NAC) conjugates were detected in the above incubations fortified with NAC. ...
N-Chloromonocrotaline was detected in both HClO/MCT incubations and MPO/H(2)O(2)/MgCl(2)/MCT incubations. DHM-derived N-acetylcysteine …
TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death.
Sun Y, Sukumaran P, Selvaraj S, Cilz NI, Schaar A, Lei S, Singh BB. Sun Y, et al. Mol Neurobiol. 2018 Jan;55(1):409-420. doi: 10.1007/s12035-016-0338-9. Epub 2016 Dec 12. Mol Neurobiol. 2018. PMID: 27957685 Free PMC article.
On the other hand, quenching of H(2)O(2) by antioxidants, resveratrol (RSV), or N-acetylcysteine (NAC) effectively blocked TRPM2-mediated Ca(2+) influx, decreased intracellular Ca(2+) overload, and increased cell survival. ...
On the other hand, quenching of H(2)O(2) by antioxidants, resveratrol (RSV), or N-acetylcysteine (NAC) effectively blocked TRPM2-medi …
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L. Zheng X, et al. Eur J Pharmacol. 2023 Oct 15;957:175969. doi: 10.1016/j.ejphar.2023.175969. Epub 2023 Aug 9. Eur J Pharmacol. 2023. PMID: 37567457
At the same time, the effect of ATH-1 was further determined by adding reactive oxygen species (ROS) inhibitor N-acetylcysteine (NAC) and CaMKII inhibitor AIP in vitro. The results showed that ATH-1 could significantly reduce the level of oxidative stress in hypertrophic c …
At the same time, the effect of ATH-1 was further determined by adding reactive oxygen species (ROS) inhibitor N-acetylcysteine (NAC) …
Proteomic and phosphoproteomic analysis of responses to enterovirus A71 infection reveals novel targets for antiviral and viral replication.
Lin D, Dong X, Xiao X, Xiang Z, Lei X, Wang J. Lin D, et al. Antiviral Res. 2023 Dec;220:105761. doi: 10.1016/j.antiviral.2023.105761. Epub 2023 Nov 21. Antiviral Res. 2023. PMID: 37992763
Notably, based on the prediction of upregulated kinases during EV-A71 infection, we identified specific kinase inhibitors approved by the FDA, with ceralasertib, bosutinib, flavin mononucleotide, minocycline, pimasertib and acetylcysteine inhibiting EV-A71 infection. Final …
Notably, based on the prediction of upregulated kinases during EV-A71 infection, we identified specific kinase inhibitors approved by the FD …
Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Shen Y, Cai W, Lei S, Zhang Z. Shen Y, et al. COPD. 2014 Jun;11(3):351-8. doi: 10.3109/15412555.2013.858315. Epub 2013 Dec 30. COPD. 2014. PMID: 24378052 Review.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide, characterised by persistent airflow limitation, mucus hypersecretion, oxidative stress and airway inflammation. N-acetylcysteine (NAC) have anti-oxidant and an …
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide, characterised by persisten …
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Sun H, Ou T, Hu J, Yang Z, Lei Q, Li Y, Wang G, Li Y, Wu K, Wang S, Wu S. Sun H, et al. Biochem Pharmacol. 2021 Aug;190:114588. doi: 10.1016/j.bcp.2021.114588. Epub 2021 May 4. Biochem Pharmacol. 2021. PMID: 33957094 Free article.
Mitochondrial reactive oxygen species (ROS) production is critical in this process, as eliminating ROS with N-acetylcysteine (NAC) efficiently inhibits PINK1 signaling-mediated mitophagy initiation and alleviates lysosomal dysfunction. ...
Mitochondrial reactive oxygen species (ROS) production is critical in this process, as eliminating ROS with N-acetylcysteine (NAC) ef …
59 results