CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
Statzu M, Jin W, Fray EJ, Wong AKH, Kumar MR, Ferrer E, Docken SS, Pinkevych M, McBrien JB, Fennessey CM, Keele BF, Liang S, Harper JL, Mutascio S, Franchitti L, Wang H, Cicetti D, Bosinger SE, Carnathan DG, Vanderford TH, Margolis DM, Garcia-Martinez JV, Chahroudi A, Paiardini M, Siliciano J, Davenport MP, Kulpa DA, Siliciano RS, Silvestri G.
Statzu M, et al.
Nat Microbiol. 2023 Feb;8(2):299-308. doi: 10.1038/s41564-022-01311-9. Epub 2023 Jan 23.
Nat Microbiol. 2023.
PMID: 36690860
Free PMC article.
Here we examined the effect of CD8(+) T cells on formation of the latent reservoir in simian immunodeficiency virus (SIV)-infected macaques by performing experimental CD8(+) depletion either before infection or before early (that is, day 14 post-infection) ART initiation. …
Here we examined the effect of CD8(+) T cells on formation of the latent reservoir in simian immunodeficiency virus (SIV)-infected ma …