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Showing results for Simos G. maintains
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Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax.
Yfantis A, Mylonis I, Simos G. Yfantis A, et al. Among authors: simos g. FEBS J. 2023 Aug;290(15):3764-3780. doi: 10.1111/febs.16762. Epub 2023 Mar 23. FEBS J. 2023. PMID: 36825991
On the contrary, unmodified HIF-1alpha is bound by chromosomal region maintenance 1 (CRM1), exits the nucleus and, via its association with mortalin, is targeted to the mitochondria to form an antiapoptotic complex. ...
On the contrary, unmodified HIF-1alpha is bound by chromosomal region maintenance 1 (CRM1), exits the nucleus and, via its associatio …
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression.
Braliou GG, Verga Falzacappa MV, Chachami G, Casanovas G, Muckenthaler MU, Simos G. Braliou GG, et al. Among authors: simos g. J Hepatol. 2008 May;48(5):801-10. doi: 10.1016/j.jhep.2007.12.021. Epub 2008 Feb 13. J Hepatol. 2008. PMID: 18313788
CONCLUSIONS: 2-Oxoglutarate-dependent oxygenases are important to maintain high hepcidin mRNA expression in a HIF-1-independent manner. ...
CONCLUSIONS: 2-Oxoglutarate-dependent oxygenases are important to maintain high hepcidin mRNA expression in a HIF-1-independent manne …
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.
Gkotinakou IM, Befani C, Simos G, Liakos P. Gkotinakou IM, et al. Among authors: simos g. J Cell Sci. 2019 Apr 8;132(7):jcs225698. doi: 10.1242/jcs.225698. J Cell Sci. 2019. PMID: 30962349
Localization, reporter gene and immunoprecipitation experiments further show that HIF-2alpha associates with the exportin chromosomal maintenance 1 (CRM1, also known as XPO1) in a phosphorylation-sensitive manner and identify two critical leucine residues as part of an aty …
Localization, reporter gene and immunoprecipitation experiments further show that HIF-2alpha associates with the exportin chromosomal mai …
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases.
Lyberopoulou A, Chachami G, Gatselis NK, Kyratzopoulou E, Saitis A, Gabeta S, Eliades P, Paraskeva E, Zachou K, Koukoulis GK, Mamalaki A, Dalekos GN, Simos G. Lyberopoulou A, et al. Among authors: simos g. PLoS One. 2015 Aug 13;10(8):e0135486. doi: 10.1371/journal.pone.0135486. eCollection 2015. PLoS One. 2015. PMID: 26270641 Free PMC article.
Both serum hepcidin and the serum hepcidin/ferritin ratio were significantly lower in AIH and PBC/PSC patients' sera compared to HBV, HCV or NAFLD (P<0.001 for each comparison) and correlated negatively with serum ALP levels. PBC/PSC and AIH patients maintained low seru …
Both serum hepcidin and the serum hepcidin/ferritin ratio were significantly lower in AIH and PBC/PSC patients' sera compared to HBV, HCV or …
Binding of lamin A to polynucleosomes.
Yuan J, Simos G, Blobel G, Georgatos SD. Yuan J, et al. Among authors: simos g. J Biol Chem. 1991 May 15;266(14):9211-5. J Biol Chem. 1991. PMID: 2026620 Free article.
This interaction is not affected by exogenous polyionic agents such as polylysine and DNA, but it can be abolished by protease digestion of the polynucleosomes. These data suggest that nuclear lamin A maintains a direct association with a proteinaceous constituent of inter …
This interaction is not affected by exogenous polyionic agents such as polylysine and DNA, but it can be abolished by protease digestion of …
The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism.
Galani K, Hurt E, Simos G. Galani K, et al. Among authors: simos g. FEBS Lett. 2005 Feb 14;579(5):969-75. doi: 10.1016/j.febslet.2004.11.112. Epub 2005 Jan 18. FEBS Lett. 2005. PMID: 15710377 Free article.
However, NLS-Arc1p accumulated in the nucleus when Xpo1/Crm1, the export receptor for NES-containing cargo proteins, was mutated. Thus, the cytoplasmic location of Arc1p is maintained by Xpo1p-dependent nuclear export and Arc1p could act as an adapter in the nucleocytoplas …
However, NLS-Arc1p accumulated in the nucleus when Xpo1/Crm1, the export receptor for NES-containing cargo proteins, was mutated. Thus, the …
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study.
Daponte A, Ioannou M, Mylonis I, Simos G, Minas M, Messinis IE, Koukoulis G. Daponte A, et al. Among authors: simos g. BMC Cancer. 2008 Nov 16;8:335. doi: 10.1186/1471-2407-8-335. BMC Cancer. 2008. PMID: 19014607 Free PMC article.
There is adequate evidence to speculate that targeting HIF-1 alpha could improve the long-term prognosis of these patients In order to increase the overall sensitivity of the immunoassay, maintaining acceptable levels of specificity, a panel of antibodies should be used... …
There is adequate evidence to speculate that targeting HIF-1 alpha could improve the long-term prognosis of these patients In order to incre …