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Page 1
Development and in vitro Profiling of Dual FXR/LTA4H Modulators.
Schierle S, Brunst S, Helmstädter M, Ebert R, Kramer JS, Steinhilber D, Proschak E, Merk D. Schierle S, et al. ChemMedChem. 2021 Aug 5;16(15):2366-2374. doi: 10.1002/cmdc.202100118. Epub 2021 May 24. ChemMedChem. 2021. PMID: 33856122 Free PMC article.
A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Helmstädter M, Vietor J, Sommer J, Schierle S, Willems S, Kaiser A, Schmidt J, Merk D. Helmstädter M, et al. Among authors: schierle s. ACS Med Chem Lett. 2021 Feb 1;12(2):267-274. doi: 10.1021/acsmedchemlett.0c00647. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603974 Free PMC article.
Development of Nuclear Receptor Modulators.
Schierle S, Merk D. Schierle S, et al. Methods Mol Biol. 2018;1824:245-260. doi: 10.1007/978-1-4939-8630-9_14. Methods Mol Biol. 2018. PMID: 30039411
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. Schierle S, et al. J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878767 Free article.
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Lillich FF, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, Kramer JS, Brunst S, Hernandez-Olmos V, Heering J, Schierle S, Kestner RI, Mayser FM, Helmstädter M, Göbel T, Weizel L, Namgaladze D, Kaiser A, Steinhilber D, Pfeilschifter W, Kahnt AS, Proschak A, Chaikuad A, Knapp S, Merk D, Proschak E. Lillich FF, et al. Among authors: schierle s. J Med Chem. 2021 Dec 9;64(23):17259-17276. doi: 10.1021/acs.jmedchem.1c01331. Epub 2021 Nov 24. J Med Chem. 2021. PMID: 34818007
18 results