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Page 1
Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci. 2023 Mar 22;24(6):5987. doi: 10.3390/ijms24065987.
Int J Mol Sci. 2023.
PMID: 36983061
Free PMC article.
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
Hu L, Wu X, Han J, Chen L, Vass SO, Browne P, Hall BS, Bot C, Gobalakrishnapillai V, Searle PF, Knox RJ, Wilkinson SR.
Hu L, et al. Among authors: vass so.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3986-91. doi: 10.1016/j.bmcl.2011.05.009. Epub 2011 May 7.
Bioorg Med Chem Lett. 2011.
PMID: 21620697
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Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Jiang Y, Han J, Yu C, Vass SO, Searle PF, Browne P, Knox RJ, Hu L.
Jiang Y, et al. Among authors: vass so.
J Med Chem. 2006 Jul 13;49(14):4333-43. doi: 10.1021/jm051246n.
J Med Chem. 2006.
PMID: 16821793
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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
Jaberipour M, Vass SO, Guise CP, Grove JI, Knox RJ, Hu L, Hyde EI, Searle PF.
Jaberipour M, et al. Among authors: vass so.
Biochem Pharmacol. 2010 Jan 15;79(2):102-11. doi: 10.1016/j.bcp.2009.07.025. Epub 2009 Aug 7.
Biochem Pharmacol. 2010.
PMID: 19665450
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