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Pharmacological Agents Targeting the Cellular Prion Protein.
Barreca ML, Iraci N, Biggi S, Cecchetti V, Biasini E. Barreca ML, et al. Among authors: biggi s. Pathogens. 2018 Mar 7;7(1):27. doi: 10.3390/pathogens7010027. Pathogens. 2018. PMID: 29518975 Free PMC article. Review.
Epidermal RAF prevents allergic skin disease.
Raguz J, Jeric I, Niault T, Nowacka JD, Kuzet SE, Rupp C, Fischer I, Biggi S, Borsello T, Baccarini M. Raguz J, et al. Among authors: biggi s. Elife. 2016 Jul 19;5:e14012. doi: 10.7554/eLife.14012. Elife. 2016. PMID: 27431613 Free PMC article.
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: biggi s. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity.
Massignan T, Sangiovanni V, Biggi S, Stincardini C, Elezgarai SR, Maietta G, Andreev IA, Ratmanova NK, Belov DS, Lukyanenko ER, Belov GM, Barreca ML, Altieri A, Kurkin AV, Biasini E. Massignan T, et al. Among authors: biggi s. ChemMedChem. 2017 Aug 22;12(16):1286-1292. doi: 10.1002/cmdc.201700302. Epub 2017 Aug 1. ChemMedChem. 2017. PMID: 28722340
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E. Stincardini C, et al. Among authors: biggi s. PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017. PLoS One. 2017. PMID: 28787011 Free PMC article.