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SIKE of black carp is a substrate of TBK1 and suppresses TBK1-mediated antiviral signaling.
Li J, Yan C, Liu J, Yan J, Feng H. Li J, et al. Dev Comp Immunol. 2019 Jan;90:157-164. doi: 10.1016/j.dci.2018.09.016. Epub 2018 Sep 22. Dev Comp Immunol. 2019. PMID: 30253130
RIG-I like receptor (RLR) signaling functions importantly in host innate immune response against RNA virus, which is tightly regulated by a number of mechanisms to prevent aberrant interferon production. The suppressor of IKKepsilon (SIKE) has been identified as a suppress …
RIG-I like receptor (RLR) signaling functions importantly in host innate immune response against RNA virus, which is tightly regulated by a …
Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin.
Ge C, Tan J, Zhong S, Lai L, Chen G, Zhao J, Yi C, Wang L, Zhou L, Tang T, Yang Q, Lou D, Li Q, Wu Y, Hu L, Kuang G, Liu X, Wang B, Xu M. Ge C, et al. Redox Biol. 2020 Sep;36:101645. doi: 10.1016/j.redox.2020.101645. Epub 2020 Jul 17. Redox Biol. 2020. PMID: 32863207 Free PMC article.
Subsequently, the gene loss- and gain-function analysis demonstrated that SIKE deficiency further aggravated inflammation and TBK1/NF-kappaB activation caused by PM(2.5), which could be abrogated by SIKE over-expression. Importantly, SIKE-alleviated inflammat …
Subsequently, the gene loss- and gain-function analysis demonstrated that SIKE deficiency further aggravated inflammation and TBK1/NF …
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB. Huang J, et al. EMBO J. 2005 Dec 7;24(23):4018-28. doi: 10.1038/sj.emboj.7600863. Epub 2005 Nov 10. EMBO J. 2005. PMID: 16281057 Free PMC article.
Knockdown of SIKE potentiated virus- and TLR3-triggered ISRE but not NF-kappaB activation. Moreover, overexpression of SIKE inhibited IKKepsilon- and TBK1-mediated antiviral response. ...
Knockdown of SIKE potentiated virus- and TLR3-triggered ISRE but not NF-kappaB activation. Moreover, overexpression of SIKE in …
Astragaloside IV protects against the pathological cardiac hypertrophy in mice.
Liu ZH, Liu HB, Wang J. Liu ZH, et al. Biomed Pharmacother. 2018 Jan;97:1468-1478. doi: 10.1016/j.biopha.2017.09.092. Epub 2017 Nov 20. Biomed Pharmacother. 2018. PMID: 29793309
In the present study, we aimed to explore the effects of AST-IV on cardiac hypertrophy induced by aortic banding (AB) surgery in mice, and to reveal the underlying signaling mechanisms. The suppressor of IKKepsilon (SIKE) is a negative regulator of the interferon pathway, …
In the present study, we aimed to explore the effects of AST-IV on cardiac hypertrophy induced by aortic banding (AB) surgery in mice, and t …