Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure

Rachedine Kaoua; Norah Bennamane; Saliha Bakhta; Sihame Benadji; Cherifa Rabia; Bellara Nedjar-Kolli

doi:10.3390/molecules16010092

Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure

Molecules. 2010 Dec 28;16(1):92-9. doi: 10.3390/molecules16010092.

Authors

Rachedine Kaoua¹, Norah Bennamane, Saliha Bakhta, Sihame Benadji, Cherifa Rabia, Bellara Nedjar-Kolli

Affiliation

¹ Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111 Algiers, Algeria.

Abstract

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine and 1,5-benzodiazepines derivatives.

MeSH terms

Acids / chemistry*
Azepines / chemical synthesis*
Azepines / chemistry
Catalysis

Substances

Acids
Azepines