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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. Zhou Y, et al. Among authors: hoffmann sc. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. Science. 2017. PMID: 29217578 Free PMC article.
Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat.
Boehn SN, Spahn S, Neudecker S, Keppler A, Bihoreau MT, Kränzlin B, Pandey P, Hoffmann SC, Li L, Torres VE, Gröne HJ, Gretz N. Boehn SN, et al. Among authors: hoffmann sc. Nephrol Dial Transplant. 2013 Aug;28(8):2045-58. doi: 10.1093/ndt/gft014. Epub 2013 Mar 29. Nephrol Dial Transplant. 2013. PMID: 23543593 Free PMC article.
A new transgenic rat model overexpressing the angiotensin II type 2 receptor provides evidence for inhibition of cell proliferation in the outer adrenal cortex.
Peters B, Podlich D, Ritter M, Müller A, Wanka H, Maser-Gluth C, Seitz C, de Boni L, Maier E, Gretz N, Peters J, Hoffmann SC. Peters B, et al. Among authors: hoffmann sc. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1044-54. doi: 10.1152/ajpendo.00080.2011. Epub 2012 Feb 7. Am J Physiol Endocrinol Metab. 2012. PMID: 22318954 Free article.