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The following term was not found in PubMed: Metusalemsson
Page 1
Sigma Receptor (sigmaR) Ligands with Antiproliferative and Anticancer Activity.
Georgiadis MO, Karoutzou O, Foscolos AS, Papanastasiou I. Georgiadis MO, et al. Molecules. 2017 Aug 25;22(9):1408. doi: 10.3390/molecules22091408. Molecules. 2017. PMID: 28841173 Free PMC article. Review.
Sigma receptor (sigmaR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various sigmaR ligands generate cancer cell death in vitro and in vivo. These …
Sigma receptor (sigmaR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have bee …
A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.
Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR. Katz JL, et al. Handb Exp Pharmacol. 2017;244:177-218. doi: 10.1007/164_2016_94. Handb Exp Pharmacol. 2017. PMID: 28110353 Review.
The literature to date suggests limited sigmaR involvement in the discriminative-stimulus effects of psychomotor stimulants, either with sigmaR agonists substituting for the stimulant or with sigmaR antagonists blocking stimulant effects. In contrast, studies …
The literature to date suggests limited sigmaR involvement in the discriminative-stimulus effects of psychomotor stimulants, either w …
[Resource conservation in surgery].
Stelzner S, Gockel I. Stelzner S, et al. Chirurgie (Heidelb). 2023 Mar;94(3):189-190. doi: 10.1007/s00104-023-01814-z. Epub 2023 Feb 23. Chirurgie (Heidelb). 2023. PMID: 36823324 German. No abstract available.
A role for sigma receptors in stimulant self-administration and addiction.
Katz JL, Hong WC, Hiranita T, Su TP. Katz JL, et al. Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):100-15. doi: 10.1097/FBP.0000000000000209. Behav Pharmacol. 2016. PMID: 26650253 Free PMC article. Review.
Sigma-1 receptors (sigma1Rs) are structurally unique intracellular proteins that function as chaperones. sigma1Rs translocate from the mitochondria-associated membrane to other subcellular compartments, and can influence a host of targets, including ion channels, G-protein-couple …
Sigma-1 receptors (sigma1Rs) are structurally unique intracellular proteins that function as chaperones. sigma1Rs translocate from the mitoc …
sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).
Paget MS, Kang JG, Roe JH, Buttner MJ. Paget MS, et al. EMBO J. 1998 Oct 1;17(19):5776-82. doi: 10.1093/emboj/17.19.5776. EMBO J. 1998. PMID: 9755177 Free PMC article.
Purified sigmaR directed transcription from trxBp1 in vitro, indicating that trxBp1 is a target for sigmaR. ...We present evidence that the sigmaR system also functions in the actinomycete pathogen Mycobacterium tuberculosis....
Purified sigmaR directed transcription from trxBp1 in vitro, indicating that trxBp1 is a target for sigmaR. ...We present evid …
The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy.
Chittaranjan S, Xu J, Kuzyk M, Dullat HK, Wilton J, DeVorkin L, Lebovitz C, Morin GB, Marra MA, Gorski SM. Chittaranjan S, et al. Biol Open. 2015 Apr 2;4(5):672-84. doi: 10.1242/bio.20148417. Biol Open. 2015. PMID: 25836674 Free PMC article.
Here we report the molecular and genetic characterization of the Drosophila TNFAIP8 homolog, CG4091/sigmar. Previous gene expression studies revealed dynamic expression of sigmar in larval salivary glands prior to histolysis. ...Further, the Drosophila TNF ligand Ei …
Here we report the molecular and genetic characterization of the Drosophila TNFAIP8 homolog, CG4091/sigmar. Previous gene expression …
Role of active drug transporters in refractory multiple myeloma.
Tucci M, Quatraro C, Dammacco F, Silvestris F. Tucci M, et al. Curr Top Med Chem. 2009;9(2):218-24. doi: 10.2174/156802609787521625. Curr Top Med Chem. 2009. PMID: 19200007 Review.
On the contrary, clinical trials with proteasome inhibitors have been successfully carried out to overcome MDR despite their toxicity profile. Recently, sigma receptors (sigmaR)(S), namely sigmaR(1) and sigmaR(2), have been found to be overexpressed in breast …
On the contrary, clinical trials with proteasome inhibitors have been successfully carried out to overcome MDR despite their toxicity profil …
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects.
Fallica AN, Ciaffaglione V, Modica MN, Pittalà V, Salerno L, Amata E, Marrazzo A, Romeo G, Intagliata S. Fallica AN, et al. Bioorg Med Chem. 2022 Nov 1;73:117032. doi: 10.1016/j.bmc.2022.117032. Epub 2022 Sep 26. Bioorg Med Chem. 2022. PMID: 36202063 Review.
The overexpression of sigma receptors (sigmaRs) in various types of tumors has prompted a deep investigation of their role in cancer pathophysiology. ...In addition to their antitumor activity, sigmaR ligands are gaining momentum as radiotracers for PET and SPECT im …
The overexpression of sigma receptors (sigmaRs) in various types of tumors has prompted a deep investigation of their role in cancer …
Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigmaR regulon.
Paget MS, Molle V, Cohen G, Aharonowitz Y, Buttner MJ. Paget MS, et al. Mol Microbiol. 2001 Nov;42(4):1007-20. doi: 10.1046/j.1365-2958.2001.02675.x. Mol Microbiol. 2001. PMID: 11737643 Free article.
In the Gram-positive, antibiotic-producing bacterium Streptomyces coelicolor A3(2), the thiol-disulphide status of the hyphae is controlled by a novel regulatory system consisting of a sigma factor, sigmaR, and its cognate anti-sigma factor, RsrA. Oxidative stress induces …
In the Gram-positive, antibiotic-producing bacterium Streptomyces coelicolor A3(2), the thiol-disulphide status of the hyphae is controlled …
276 results