Lysine catabolism reprograms tumour immunity through histone crotonylation.
Yuan H, Wu X, Wu Q, Chatoff A, Megill E, Gao J, Huang T, Duan T, Yang K, Jin C, Yuan F, Wang S, Zhao L, Zinn PO, Abdullah KG, Zhao Y, Snyder NW, Rich JN.
Yuan H, et al.
Nature. 2023 May;617(7962):818-826. doi: 10.1038/s41586-023-06061-0. Epub 2023 May 17.
Nature. 2023.
PMID: 37198486
Free PMC article.
A lysine-restricted diet synergized with MYC inhibition or anti-PD-1 therapy to slow tumour growth. Collectively, GSCs co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic ef …
A lysine-restricted diet synergized with MYC inhibition or anti-PD-1 therapy to slow tumour growth. Collectively, GSCs co-opt lysine uptake …