Nowadays CT colonoscopy is one of the basic methods for colon disease diagnostic. In Georgia mentioned method is used rarely despite of its high diagnostic potential. The current research aims to populate CT colonoscopy to be widely used in diagnostic as well as preventive healthcare, develop radiological semiotics of colon specifications and pathology changes. The research have been carried out in Batumi Referral Hospital. During the clinical researches patient's complains were gathered in details , also there was considered life , medical history and clinical research data. Following instrumental methods were used: CT colonoscopy, fibrocolonoscopy, irrigography-irrigoscopy, ultrasound research of colon. Computer Tomography researches was carried out on "General Electric" (USA) 16 layer CT scanner with 1.2 mm step by following phases: definition of research indication, preparation of intestine, insufflation, getting image, working on image and interpretation. In all cases intenstine was filled up with common air by manually method. According to 224 patients examination results in colon growing anomalies diagnostic CT colonoscopy responsivity is 98,0%, specificity 100%, diagnostic accuracy 98,2%, diverticulosis diagnostic 92,3%, 95,1%, 92,7%, and accordingly polyps in diagnostic: 87,3%, 85,6%, 85,9%. According to the gained results we can make conclusion, that CT colonoscopy is a reliable, high informational and minimally invasive diagnostic method to discover pathological disorder in colon wall and early stage cancer.