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Showing results for shigeno fu
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The natural course of unruptured cerebral aneurysms in a Japanese cohort.
UCAS Japan Investigators; Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, Hashimoto N, Nakayama T, Sakai M, Teramoto A, Tominari S, Yoshimoto T. UCAS Japan Investigators, et al. N Engl J Med. 2012 Jun 28;366(26):2474-82. doi: 10.1056/NEJMoa1113260. N Engl J Med. 2012. PMID: 22738097 Free article.
Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner.
Fujimoto K, Takematsu YK, Shigeno A, Furusawa M, Sakamoto T. Fujimoto K, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3736-8. doi: 10.1016/j.bmcl.2014.07.002. Epub 2014 Jul 14. Bioorg Med Chem Lett. 2014. PMID: 25080163
Photo-induced C1' hydrogen abstraction of 5-fluoro-2'-deoxyuridine was adopted as the key reaction for releasing 5-fluorouracil (5-FU) anticancer drug from oligonucleotide strands. After photoirradiation following 5-FU release, anticancer activity was expected. We d …
Photo-induced C1' hydrogen abstraction of 5-fluoro-2'-deoxyuridine was adopted as the key reaction for releasing 5-fluorouracil (5-FU …