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2005 1
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Page 1
Did you mean shi jie ru (4 results)?
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
Xiong W, Gao X, Zhang T, Jiang B, Hu MM, Bu X, Gao Y, Zhang LZ, Xiao BL, He C, Sun Y, Li H, Shi J, Xiao X, Xiang B, Xie C, Chen G, Zhang H, Wei W, Freeman GJ, Shu HB, Wang H, Zhang J. Xiong W, et al. Nat Commun. 2022 Mar 31;13(1):1700. doi: 10.1038/s41467-022-29401-6. Nat Commun. 2022. PMID: 35361799 Free PMC article.
Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15-25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. ... …
Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the under …
NLRP3 inflammasome contributes to endotoxin-induced coagulation.
Shi J, Tang Y, Liang F, Liu L, Liang N, Yang X, Zhang N, Yi Z, Zhong Y, Wang W, Zhao K. Shi J, et al. Thromb Res. 2022 Jun;214:8-15. doi: 10.1016/j.thromres.2022.04.001. Epub 2022 Apr 8. Thromb Res. 2022. PMID: 35421682
These findings broadened our understanding of the mechanism of coagulation and implicated a possible therapeutic strategy for preventing coagulation in sepsis....
These findings broadened our understanding of the mechanism of coagulation and implicated a possible therapeutic strategy for prevent …
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J. Xiao X, et al. Nat Commun. 2023 May 19;14(1):2859. doi: 10.1038/s41467-023-38605-3. Nat Commun. 2023. PMID: 37208329 Free PMC article.
Together, this study describes a molecular mechanism of ERK/USP5-mediated regulation of PD-1 and identifies potential combinatorial therapeutic strategies for enhancing anti-tumor efficacy....
Together, this study describes a molecular mechanism of ERK/USP5-mediated regulation of PD-1 and identifies potential combinatorial thera …
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S. Wei X, et al. J Clin Oncol. 2019 Aug 20;37(24):2141-2151. doi: 10.1200/JCO.18.02184. Epub 2019 Jul 8. J Clin Oncol. 2019. PMID: 31283409 Free PMC article. Clinical Trial.
The modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines were used to evaluate the therapeutic effects of RT. The primary end point was overall survival. ...
The modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines were used to evaluate the therapeutic effects of RT. T …
Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway.
Wang WB, Li JT, Hui Y, Shi J, Wang XY, Yan SG. Wang WB, et al. Chin Med. 2022 Feb 5;17(1):19. doi: 10.1186/s13020-021-00562-8. Chin Med. 2022. PMID: 35123524 Free PMC article.
Those in the control and LPS groups were given intragastric administrations of physiological saline, rats in other groups were given intragastrically administered of differential dose therapeutic agents. The rats in the LPS and treatment groups were then injected intraperi …
Those in the control and LPS groups were given intragastric administrations of physiological saline, rats in other groups were given intraga …
Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition).
Yang Y, Sun J, Wu M, Lau WY, Zheng S, Wang XH, Chen X, Fan J, Dong J, Cai J, Chen M, Chen Y, Cheng Z, Dai C, Shan J, Du CY, Fang C, Hu H, Ji Z, Jia W, Li G, Li J, Li J, Liu C, Liu F, Ma Y, Mao Y, Niu Z, Shen J, Shi J, Shi X, Song W, Sun HC, Tan G, Tao R, Wang X, Wen T, Wu L, Xia J, Xiang BD, Yan M, Ying M, Zhang L, Zhang X, Zeng ZC, Zhang Y, Zhang Z, Zhou J, Zhou C, Zhou J, Zhou L, Zhou X, Zhu J, Zhu Z, Zhang Q, Li Q, Cheng S. Yang Y, et al. Liver Cancer. 2022 Jul 20;11(6):511-526. doi: 10.1159/000526038. eCollection 2022 Dec. Liver Cancer. 2022. PMID: 36589726 Free PMC article. Review.
SUMMARY: In recent years, immune checkpoint inhibitors have made a breakthrough in the systemic treatment of middle-advanced HCC, breaking the single therapeutic pattern of molecular-targeted agents. To better guide the clinical treatment for effective and safe use of immu …
SUMMARY: In recent years, immune checkpoint inhibitors have made a breakthrough in the systemic treatment of middle-advanced HCC, breaking t …
KRAS4A directly regulates hexokinase 1.
Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR. Amendola CR, et al. Nature. 2019 Dec;576(7787):482-486. doi: 10.1038/s41586-019-1832-9. Epub 2019 Dec 11. Nature. 2019. PMID: 31827279 Free PMC article.
210 results