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MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.
Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH. Nagahara AH, et al. Gene Ther. 2018 Apr;25(2):104-114. doi: 10.1038/s41434-018-0010-2. Epub 2018 Mar 13. Gene Ther. 2018. PMID: 29535375 Free PMC article.
Using MRI-guided methods with convection-enhanced delivery, we were able to accurately and consistently target AAV2-BDNF delivery to the entorhinal cortex of non-human primates; 86 3% of transduced cells in the targeted regions co-localized with the neuronal marker NeuN. T …
Using MRI-guided methods with convection-enhanced delivery, we were able to accurately and consistently target AAV2-BDNF delivery to the ent …
Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline.
Carrasco-Garcia E, Arrizabalaga O, Serrano M, Lovell-Badge R, Matheu A. Carrasco-Garcia E, et al. Aging Cell. 2015 Aug;14(4):710-4. doi: 10.1111/acel.12343. Epub 2015 May 20. Aging Cell. 2015. PMID: 25990896 Free PMC article.
Furthermore, aged s-Ink4/Arf/p53 mice express higher levels of Doublecortin and PSA-NCAM (neuroblasts) and NeuN (neurons) in the olfactory bulbs (OB) and DG, indicating increased neurogenesis in vivo. ...
Furthermore, aged s-Ink4/Arf/p53 mice express higher levels of Doublecortin and PSA-NCAM (neuroblasts) and NeuN (neurons) in the olfa …
Niche-dependent development of functional neuronal networks from embryonic stem cell-derived neural populations.
Illes S, Theiss S, Hartung HP, Siebler M, Dihné M. Illes S, et al. BMC Neurosci. 2009 Aug 6;10:93. doi: 10.1186/1471-2202-10-93. BMC Neurosci. 2009. PMID: 19660102 Free PMC article.
RESULTS: While both precursor populations were shown to differentiate into sufficient quantities of mature NeuN+ neurons that also express GABA or vesicular-glutamate-transporter-2 (vGlut2), only aggregate-derived neuronal populations exhibited a synchronously oscillating …
RESULTS: While both precursor populations were shown to differentiate into sufficient quantities of mature NeuN+ neurons that also ex …