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Year Number of Results
2002 2
2004 3
2005 2
2006 1
2007 1
2009 1
2015 4
2017 1
2018 3
2019 1
2020 2
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2022 1
2024 0

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Page 1
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).
Policarpo RL, Decultot L, May E, Kuzmič P, Carlson S, Huang D, Chu V, Wright BA, Dhakshinamoorthy S, Kannt A, Rani S, Dittakavi S, Panarese JD, Gaudet R, Shair MD. Policarpo RL, et al. Among authors: dhakshinamoorthy s. J Med Chem. 2019 Nov 14;62(21):9837-9873. doi: 10.1021/acs.jmedchem.9b01238. Epub 2019 Oct 25. J Med Chem. 2019. PMID: 31589440 Free PMC article.
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Ruf S, Hallur MS, Anchan NK, Swamy IN, Murugesan KR, Sarkar S, Narasimhulu LK, Putta VPRK, Shaik S, Chandrasekar DV, Mane VS, Kadnur SV, Suresh J, Bhamidipati RK, Singh M, Burri RR, Kristam R, Schreuder H, Czech J, Rudolph C, Marker A, Langer T, Mullangi R, Yura T, Gosu R, Kannt A, Dhakshinamoorthy S, Rajagopal S. Ruf S, et al. Among authors: dhakshinamoorthy s. Bioorg Med Chem Lett. 2018 Mar 1;28(5):922-925. doi: 10.1016/j.bmcl.2018.01.058. Epub 2018 Jan 31. Bioorg Med Chem Lett. 2018. PMID: 29433927
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Ruf S, Rajagopal S, Kadnur SV, Hallur MS, Rani S, Kristam R, Swaminathan S, Zope BR, Gondrala PK, Swamy I, Putta VPRK, Kandan S, Zech G, Schreuder H, Rudolph C, Elvert R, Czech J, Birudukota S, Siddiqui MA, Anand NN, Mane VS, Dittakavi S, Suresh J, Gosu R, Ramesh M, Yura T, Dhakshinamoorthy S, Kannt A. Ruf S, et al. Among authors: dhakshinamoorthy s. Sci Rep. 2022 Sep 14;12(1):15440. doi: 10.1038/s41598-022-19634-2. Sci Rep. 2022. PMID: 36104373 Free PMC article.
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S. Kannt A, et al. Among authors: dhakshinamoorthy s. Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7. Sci Rep. 2018. PMID: 29483571 Free PMC article.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Swaminathan S, Birudukota S, Thakur MK, Parveen R, Kandan S, Juluri S, Shaik S, Anand NN, Burri RR, Kristam R, Hallur MS, Rajagopal S, Schreuder H, Langer T, Rudolph C, Ruf S, Dhakshinamoorthy S, Gosu R, Kannt A. Swaminathan S, et al. Among authors: dhakshinamoorthy s. Biochem Biophys Res Commun. 2017 Sep 16;491(2):416-422. doi: 10.1016/j.bbrc.2017.07.087. Epub 2017 Jul 15. Biochem Biophys Res Commun. 2017. PMID: 28720493
ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score.
Sanjay KV, Vishwakarma S, Zope BR, Mane VS, Mohire S, Dhakshinamoorthy S. Sanjay KV, et al. Among authors: dhakshinamoorthy s. Curr Res Pharmacol Drug Discov. 2021 Sep 4;2:100051. doi: 10.1016/j.crphar.2021.100051. eCollection 2021. Curr Res Pharmacol Drug Discov. 2021. PMID: 34909677 Free PMC article.
24 results