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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166. Epub 2016 Aug 29.
Nat Chem Biol. 2016.
PMID: 27571479
Free PMC article.
FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.
Tsai JW, Cejas P, Wang DK, Patel S, Wu DW, Arounleut P, Wei X, Zhou N, Syamala S, Dubois FPB, Crane A, Pelton K, Vogelzang J, Sousa C, Baguette A, Chen X, Condurat AL, Dixon-Clarke SE, Zhou KN, Lu SD, Gonzalez EM, Chacon MS, Digiacomo JJ, Kumbhani R, Novikov D, Hunter J, Tsoli M, Ziegler DS, Dirksen U, Jager N, Balasubramanian GP, Kramm CM, Nathrath M, Bielack S, Baker SJ, Zhang J, McFarland JM, Getz G, Aguet F, Jabado N, Witt O, Pfister SM, Ligon KL, Hovestadt V, Kleinman CL, Long H, Jones DTW, Bandopadhayay P, Phoenix TN.
Tsai JW, et al. Among authors: dixon clarke se.
Cancer Res. 2022 Sep 2;82(17):2980-3001. doi: 10.1158/0008-5472.CAN-22-0671.
Cancer Res. 2022.
PMID: 35802025
Free PMC article.
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Dietary inhibitors of monoamine oxidase A.
Dixon Clarke SE, Ramsay RR.
Dixon Clarke SE, et al.
J Neural Transm (Vienna). 2011 Jul;118(7):1031-41. doi: 10.1007/s00702-010-0537-x. Epub 2010 Dec 29.
J Neural Transm (Vienna). 2011.
PMID: 21190052
Review.
Item in Clipboard
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery.
Wu T, Yoon H, Xiong Y, Dixon-Clarke SE, Nowak RP, Fischer ES.
Wu T, et al. Among authors: dixon clarke se.
Nat Struct Mol Biol. 2020 Jul;27(7):605-614. doi: 10.1038/s41594-020-0438-0. Epub 2020 Jun 15.
Nat Struct Mol Biol. 2020.
PMID: 32541897
Free PMC article.
Review.
Item in Clipboard
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Dixon-Clarke SE, Shehata SN, Krojer T, Sharpe TD, von Delft F, Sakamoto K, Bullock AN.
Dixon-Clarke SE, et al.
Biochem J. 2017 Feb 20;474(5):699-713. doi: 10.1042/BCJ20160941.
Biochem J. 2017.
PMID: 28057719
Free PMC article.
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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
Nonga OE, Lavogina D, Enkvist E, Kestav K, Chaikuad A, Dixon-Clarke SE, Bullock AN, Kopanchuk S, Ivan T, Ekambaram R, Viht K, Knapp S, Uri A.
Nonga OE, et al. Among authors: dixon clarke se.
Molecules. 2021 Jul 19;26(14):4353. doi: 10.3390/molecules26144353.
Molecules. 2021.
PMID: 34299628
Free PMC article.
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Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN.
Dixon-Clarke SE, et al.
Sci Rep. 2015 Nov 24;5:17122. doi: 10.1038/srep17122.
Sci Rep. 2015.
PMID: 26597175
Free PMC article.
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