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Current status and future perspectives in targeted therapy of NPM1-mutated AML.
Ranieri R, Pianigiani G, Sciabolacci S, Perriello VM, Marra A, Cardinali V, Pierangeli S, Milano F, Gionfriddo I, Brunetti L, Martelli MP, Falini B. Ranieri R, et al. Among authors: pierangeli s. Leukemia. 2022 Oct;36(10):2351-2367. doi: 10.1038/s41375-022-01666-2. Epub 2022 Aug 25. Leukemia. 2022. PMID: 36008542 Free PMC article. Review.
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.
Gionfriddo I, Brunetti L, Mezzasoma F, Milano F, Cardinali V, Ranieri R, Venanzi A, Pierangeli S, Vetro C, Spinozzi G, Dorillo E, Wu HC, Berthier C, Ciurnelli R, Griffin MJ, Jennings CE, Tiacci E, Sportoletti P, Falzetti F, de Thé H, Veal GJ, Martelli MP, Falini B. Gionfriddo I, et al. Among authors: pierangeli s. Leukemia. 2021 Sep;35(9):2552-2562. doi: 10.1038/s41375-021-01192-7. Epub 2021 Mar 2. Leukemia. 2021. PMID: 33654209 Free PMC article. Clinical Trial.
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
Martelli MP, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B. Martelli MP, et al. Among authors: pierangeli s. Blood. 2015 May 28;125(22):3455-65. doi: 10.1182/blood-2014-11-611459. Epub 2015 Mar 20. Blood. 2015. PMID: 25795919 Free article.