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Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells.
Rodrigues ACBDC, Bomfim LM, Neves SP, Soares MBP, Dias RB, Valverde LF, Rocha CAG, Costa EV, da Silva FMA, Rocha WC, Koolen HHF, Bezerra DP. Rodrigues ACBDC, et al. Among authors: neves sp. Biomed Pharmacother. 2021 Oct;142:112034. doi: 10.1016/j.biopha.2021.112034. Epub 2021 Aug 16. Biomed Pharmacother. 2021. PMID: 34411914 Free article.
A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway.
de Carvalho NC, Neves SP, Dias RB, Valverde LF, Sales CBS, Rocha CAG, Soares MBP, Dos Santos ER, Oliveira RMM, Carlos RM, Nogueira PCL, Bezerra DP. de Carvalho NC, et al. Among authors: neves sp. Cell Death Dis. 2018 Jan 23;9(2):79. doi: 10.1038/s41419-017-0104-6. Cell Death Dis. 2018. PMID: 29362398 Free PMC article.