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A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response.
Lainšček D, Fink T, Forstnerič V, Hafner-Bratkovič I, Orehek S, Strmšek Ž, Manček-Keber M, Pečan P, Esih H, Malenšek Š, Aupič J, Dekleva P, Plaper T, Vidmar S, Kadunc L, Benčina M, Omersa N, Anderluh G, Pojer F, Lau K, Hacker D, Correia BE, Peterhoff D, Wagner R, Bergant V, Herrmann A, Pichlmair A, Jerala R. Lainšček D, et al. Among authors: orehek s. Vaccines (Basel). 2021 Apr 27;9(5):431. doi: 10.3390/vaccines9050431. Vaccines (Basel). 2021. PMID: 33925446 Free PMC article.
Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs.
Manček-Keber M, Hafner-Bratkovič I, Lainšček D, Benčina M, Govednik T, Orehek S, Plaper T, Jazbec V, Bergant V, Grass V, Pichlmair A, Jerala R. Manček-Keber M, et al. Among authors: orehek s. FASEB J. 2021 Jun;35(6):e21651. doi: 10.1096/fj.202100560R. FASEB J. 2021. PMID: 34004056 Free PMC article.
Sequestration of membrane cholesterol by cholesterol-binding proteins inhibits SARS-CoV-2 entry into Vero E6 cells.
Kulma M, Šakanović A, Bedina-Zavec A, Caserman S, Omersa N, Šolinc G, Orehek S, Hafner-Bratkovič I, Kuhar U, Slavec B, Krapež U, Ocepek M, Kobayashi T, Kwiatkowska K, Jerala R, Podobnik M, Anderluh G. Kulma M, et al. Among authors: orehek s. Biochem Biophys Res Commun. 2024 Apr 16;716:149954. doi: 10.1016/j.bbrc.2024.149954. Online ahead of print. Biochem Biophys Res Commun. 2024. PMID: 38704887