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Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity.
Rujas E, Cui H, Burnie J, Aschner CB, Zhao T, Insausti S, Muthuraman K, Semesi A, Ophel J, Nieva JL, Seaman MS, Guzzo C, Treanor B, Julien JP. Rujas E, et al. Among authors: insausti s. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2112887119. doi: 10.1073/pnas.2112887119. Proc Natl Acad Sci U S A. 2022. PMID: 35064083 Free PMC article.
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
Torralba J, de la Arada I, Partida-Hanon A, Rujas E, Arribas M, Insausti S, Valotteau C, Valle J, Andreu D, Caaveiro JMM, Jiménez MA, Apellániz B, Redondo-Morata L, Nieva JL. Torralba J, et al. Among authors: insausti s. Commun Biol. 2022 Nov 18;5(1):1265. doi: 10.1038/s42003-022-04219-6. Commun Biol. 2022. PMID: 36400835 Free PMC article.
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
Rujas E, Insausti S, Leaman DP, Carravilla P, González-Resines S, Monceaux V, Sánchez-Eugenia R, García-Porras M, Iloro I, Zhang L, Elortza F, Julien JP, Saéz-Cirión A, Zwick MB, Eggeling C, Ojida A, Domene C, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: insausti s. Cell Rep. 2020 Aug 18;32(7):108037. doi: 10.1016/j.celrep.2020.108037. Cell Rep. 2020. PMID: 32814041 Free PMC article.
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: insausti s. iScience. 2021 Aug 17;24(9):102987. doi: 10.1016/j.isci.2021.102987. eCollection 2021 Sep 24. iScience. 2021. PMID: 34505005 Free PMC article.
12 results