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α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.
Sato M, Evans BA, Sandström AL, Chia LY, Mukaida S, Thai BS, Nguyen A, Lim L, Tan CYR, Baltos JA, White PJ, May LT, Hutchinson DS, Summers RJ, Bengtsson T. Sato M, et al. Among authors: mukaida s. Biochem Pharmacol. 2018 Feb;148:27-40. doi: 10.1016/j.bcp.2017.11.016. Epub 2017 Nov 24. Biochem Pharmacol. 2018. PMID: 29175420 Free article.
The metabolic effects of mirabegron are mediated primarily by β3 -adrenoceptors.
Dehvari N, Sato M, Bokhari MH, Kalinovich A, Ham S, Gao J, Nguyen HTM, Whiting L, Mukaida S, Merlin J, Chia LY, Wootten D, Summers RJ, Evans BA, Bengtsson T, Hutchinson DS. Dehvari N, et al. Among authors: mukaida s. Pharmacol Res Perspect. 2020 Oct;8(5):e00643. doi: 10.1002/prp2.643. Pharmacol Res Perspect. 2020. PMID: 32813332 Free PMC article.
BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization.
Mukaida S, Sato M, Öberg AI, Dehvari N, Olsen JM, Kocan M, Halls ML, Merlin J, Sandström AL, Csikasz RI, Evans BA, Summers RJ, Hutchinson DS, Bengtsson T. Mukaida S, et al. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R666-R677. doi: 10.1152/ajpregu.00285.2018. Epub 2019 Mar 20. Am J Physiol Regul Integr Comp Physiol. 2019. PMID: 30892909 Free article.