Fluoroquinolone resistance in Streptococcus pyogenes

Sandra S Richter; Daniel J Diekema; Kris P Heilmann; Laurel S Almer; Virginia D Shortridge; Rod Zeitler; Robert K Flamm; Gary V Doern

doi:10.1086/345904

Fluoroquinolone resistance in Streptococcus pyogenes

Clin Infect Dis. 2003 Feb 1;36(3):380-3. doi: 10.1086/345904. Epub 2003 Jan 14.

Authors

Sandra S Richter¹, Daniel J Diekema, Kris P Heilmann, Laurel S Almer, Virginia D Shortridge, Rod Zeitler, Robert K Flamm, Gary V Doern

Affiliation

¹ Department of Pathology, University of Iowa Healthcare, Iowa City, Iowa 52242, USA. sandra-richter@uiowa.edu

PMID: 12539083
DOI: 10.1086/345904

Abstract

Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 microg/mL) was found. DNA amplification and sequencing revealed a serine81-->tyrosine substitution in gyrA and 2 substitutions in parC: serine79-->phenylalanine and alanine121-->valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

Publication types

Case Reports

MeSH terms

Amino Acid Substitution
Anti-Infective Agents / pharmacology*
DNA Gyrase / genetics*
DNA Topoisomerase IV / genetics*
Drug Resistance, Bacterial / genetics*
Female
Humans
Levofloxacin
Microbial Sensitivity Tests
Ofloxacin / pharmacology
Streptococcal Infections / microbiology
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics
Streptococcus pyogenes / isolation & purification

Substances

Anti-Infective Agents
Levofloxacin
Ofloxacin
DNA Topoisomerase IV
DNA Gyrase