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1996 1
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2005 1
2006 1
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2009 1
2011 1
2012 2
2013 1
2014 2
2015 2
2016 5
2017 2
2018 3
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2020 3
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2023 3
2024 0

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45 results

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Page 1
Showing results for sandra arrest
Search for Sandra Arest instead (1 results)
Detection of immunogenic cell death and its relevance for cancer therapy.
Fucikova J, Kepp O, Kasikova L, Petroni G, Yamazaki T, Liu P, Zhao L, Spisek R, Kroemer G, Galluzzi L. Fucikova J, et al. Cell Death Dis. 2020 Nov 26;11(11):1013. doi: 10.1038/s41419-020-03221-2. Cell Death Dis. 2020. PMID: 33243969 Free PMC article. Review.
Additional hallmarks of ICD encompass the phosphorylation of eukaryotic translation initiation factor 2 subunit-alpha (EIF2S1, better known as eIF2alpha), the activation of autophagy, and a global arrest in transcription and translation. Here, we outline methodological app …
Additional hallmarks of ICD encompass the phosphorylation of eukaryotic translation initiation factor 2 subunit-alpha (EIF2S1, better known …
The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders.
Saffari A, Lau T, Tajsharghi H, Karimiani EG, Kariminejad A, Efthymiou S, Zifarelli G, Sultan T, Toosi MB, Sedighzadeh S, Siu VM, Ortigoza-Escobar JD, AlShamsi AM, Ibrahim S, Al-Sannaa NA, Al-Hertani W, Sandra W, Tarnopolsky M, Alavi S, Li C, Day-Salvatore DL, Martínez-González MJ, Levandoski KM, Bedoukian E, Madan-Khetarpal S, Idleburg MJ, Menezes MJ, Siddharth A, Platzer K, Oppermann H, Smitka M, Collins F, Lek M, Shahrooei M, Ghavideldarestani M, Herman I, Rendu J, Faure J, Baker J, Bhambhani V, Calderwood L, Akhondian J, Imannezhad S, Mirzadeh HS, Hashemi N, Doosti M, Safi M, Ahangari N, Torbati PN, Abedini S, Salpietro V, Gulec EY, Eshaghian S, Ghazavi M, Pascher MT, Vogel M, Abicht A, Moutton S, Bruel AL, Rieubland C, Gallati S, Strom TM, Lochmüller H, Mohammadi MH, Alvi JR, Zackai EH, Keena BA, Skraban CM, Berger SI, Andrew EH, Rahimian E, Morrow MM, Wentzensen IM, Millan F, Henderson LB, Dafsari HS, Jungbluth H, Gomez-Ospina N, McRae A, Peter M, Veltra D, Marinakis NM, Sofocleous C, Ashrafzadeh F, Pehlivan D, Lemke JR, Melki J, Benezit A, Bauer P, Weis D, Lupski JR, Senderek J, Christodoulou J, Chung WK, Goodchild R, Offiah AC, Moreno-De-Luca A, Suri M, Ebrahimi-Fakhari D,… See abstract for full author list ➔ Saffari A, et al. Brain. 2023 Aug 1;146(8):3273-3288. doi: 10.1093/brain/awad039. Brain. 2023. PMID: 36757831 Free PMC article.
Death occurred at a median age of 1.2 months (1 week-9 years), due to respiratory failure, cardiac arrest or sepsis. Analysis of brain MRI studies identified non-specific neuroimaging features, including a hypoplastic corpus callosum (72%), foci of signal abnormality in th …
Death occurred at a median age of 1.2 months (1 week-9 years), due to respiratory failure, cardiac arrest or sepsis. Analysis of brai …
Immune recognition of irradiated cancer cells.
Wennerberg E, Vanpouille-Box C, Bornstein S, Yamazaki T, Demaria S, Galluzzi L. Wennerberg E, et al. Immunol Rev. 2017 Nov;280(1):220-230. doi: 10.1111/imr.12568. Immunol Rev. 2017. PMID: 29027232 Free PMC article. Review.
Indeed, the macromolecular damage imposed to malignant cells by RT initiates one or multiple signal transduction cascades that drive a permanent proliferative arrest (cellular senescence) or regulated cell death. Both these phenomena show a rather linear dose-response corr …
Indeed, the macromolecular damage imposed to malignant cells by RT initiates one or multiple signal transduction cascades that drive a perma …
CRISPR: Stressed about p53?
Foronda M, Dow LE. Foronda M, et al. Trends Mol Med. 2018 Sep;24(9):731-733. doi: 10.1016/j.molmed.2018.06.010. Epub 2018 Jul 17. Trends Mol Med. 2018. PMID: 30017531
Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle arrest. These findings may help to explain why CRISPR-mediated genetic manipulation in different cell types leads to dissimilar outcomes …
Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle …
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Dai X, et al. Nat Med. 2017 Sep;23(9):1063-1071. doi: 10.1038/nm.4378. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805820 Free PMC article.
As a result, prostate cancer cell lines and organoids derived from individuals harboring SPOP mutations are more resistant to BET-inhibitor-induced cell growth arrest and apoptosis. Therefore, our results elucidate the tumor-suppressor role of SPOP in prostate cancer in wh …
As a result, prostate cancer cell lines and organoids derived from individuals harboring SPOP mutations are more resistant to BET-inhibitor- …
Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target.
Ningarhari M, Caruso S, Hirsch TZ, Bayard Q, Franconi A, Védie AL, Noblet B, Blanc JF, Amaddeo G, Ganne N, Ziol M, Paradis V, Guettier C, Calderaro J, Morcrette G, Kim Y, MacLeod AR, Nault JC, Rebouissou S, Zucman-Rossi J. Ningarhari M, et al. J Hepatol. 2021 May;74(5):1155-1166. doi: 10.1016/j.jhep.2020.11.052. Epub 2020 Dec 15. J Hepatol. 2021. PMID: 33338512 Free article.
In HCC cell lines, TERT silencing with ASO was efficient in highly proliferative and poorly differentiated cells. Treatment for 3 to 16 weeks induced cell proliferation arrest in 12 cell lines through telomere shortening, DNA damage and activation of apoptosis. ...
In HCC cell lines, TERT silencing with ASO was efficient in highly proliferative and poorly differentiated cells. Treatment for 3 to 16 week …
Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors.
Klapp V, Buqué A, Bloy N, Sato A, Yamazaki T, Zhou XK, Formenti SC, Galluzzi L, Petroni G. Klapp V, et al. J Transl Med. 2023 Feb 10;21(1):110. doi: 10.1186/s12967-023-03964-4. J Transl Med. 2023. PMID: 36765430 Free PMC article.
Depending on tumor model, cellular senescence (an irreversible proliferative arrest that is associated with the secretion of numerous bioactive factors) has been attributed beneficial or detrimental effects on response to treatment. ...
Depending on tumor model, cellular senescence (an irreversible proliferative arrest that is associated with the secretion of numerous …
Narrative review of current and emerging pharmacological therapies for nonalcoholic steatohepatitis.
Satiya J, Snyder HS, Singh SP, Satapathy SK. Satiya J, et al. Transl Gastroenterol Hepatol. 2021 Oct 25;6:60. doi: 10.21037/tgh-20-247. eCollection 2021. Transl Gastroenterol Hepatol. 2021. PMID: 34805582 Free PMC article. Review.
Although lifestyle modifications including dietary modifications and physical activity remain the mainstay of therapy, there is an unmet need to develop a drug or a combination of drugs which can not only reduce the fatty infiltration of the liver, but also arrest the deve …
Although lifestyle modifications including dietary modifications and physical activity remain the mainstay of therapy, there is an unmet nee …
Tankyrase inhibition sensitizes cells to CDK4 blockade.
Foronda M, Tarumoto Y, Schatoff EM, Leach BI, Diaz BJ, Zimmerman J, Goswami S, Shusterman M, Vakoc CR, Dow LE. Foronda M, et al. PLoS One. 2019 Dec 31;14(12):e0226645. doi: 10.1371/journal.pone.0226645. eCollection 2019. PLoS One. 2019. PMID: 31891587 Free PMC article.
We show that the loss of CDK4, but not CDK6, synergizes with TNKS1/2 blockade to drive G1 cell cycle arrest and senescence. Through precise modelling of cancer-associated mutations using cytidine base editors, we show that this therapeutic approach is absolutely dependent …
We show that the loss of CDK4, but not CDK6, synergizes with TNKS1/2 blockade to drive G1 cell cycle arrest and senescence. Through p …
Hyperoxia and mortality in conventional versus extracorporeal cardiopulmonary resuscitation.
Stoll SE, Paul E, Pilcher D, Udy A, Burrell A. Stoll SE, et al. J Crit Care. 2022 Jun;69:154001. doi: 10.1016/j.jcrc.2022.154001. Epub 2022 Feb 23. J Crit Care. 2022. PMID: 35217372
PURPOSE: Hyperoxia has been associated with adverse outcomes in post cardiac arrest (CA) patients. Study-objective was to examine the association between hyperoxia and 30-day mortality in a mixed cohort of two different modes of Cardiopulmonary Resuscitation (CPR): Extraco …
PURPOSE: Hyperoxia has been associated with adverse outcomes in post cardiac arrest (CA) patients. Study-objective was to examine the …
45 results