Abstract
A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively.
Keywords:
Anonaceae; Orophea enterocarpa; aristolactam; cytotoxicities; human colon adenocarcinoma cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy
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Annonaceae / metabolism*
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Cell Line, Tumor
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Cell Survival / drug effects
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Colonic Neoplasms / drug therapy*
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Drug Discovery
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Humans
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / metabolism
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Indole Alkaloids / pharmacology*
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Lactams / isolation & purification
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Lactams / metabolism
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Lactams / pharmacology*
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Molecular Structure
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
Substances
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Indole Alkaloids
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Lactams
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Phenanthrenes
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Plant Extracts
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stigmalactam