A simple synthesis of 2-thiohydantoins

Zerong Daniel Wang; Samia O Sheikh; Yulu Zhang

doi:10.3390/11100739

A simple synthesis of 2-thiohydantoins

Molecules. 2006 Oct 2;11(10):739-50. doi: 10.3390/11100739.

Authors

Zerong Daniel Wang¹, Samia O Sheikh, Yulu Zhang

Affiliation

¹ Department of Chemistry, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, TX 77058, USA. wang@uhcl.edu

Abstract

2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an alpha-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Temperature
Thiohydantoins / chemical synthesis*
Thiohydantoins / chemistry
Thiourea / chemistry
Time Factors

Substances

Amino Acids
Thiohydantoins
Thiourea