Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice.
Hunt C, Hartford SA, White D, Pefanis E, Hanna T, Herman C, Wiley J, Brown H, Su Q, Xin Y, Voronin D, Nguyen H, Altarejos J, Crosby K, Haines J, Cancelarich S, Drummond M, Moller-Tank S, Malpass R, Buckley J, Del Pilar Molina-Portela M, Droguett G, Frendewey D, Chiao E, Zambrowicz B, Gong G.
Hunt C, et al.
Nat Commun. 2021 May 13;12(1):2770. doi: 10.1038/s41467-021-22932-4.
Nat Commun. 2021.
PMID: 33986266
Free PMC article.
Additionally, we applied SAM to optimize gene expression in a humanized Transthyretin mouse model to recapitulate human expression levels. These results demonstrate that the SAM gene activation platform can facilitate in vivo research and drug discovery....
Additionally, we applied SAM to optimize gene expression in a humanized Transthyretin mouse model to recapitulate human expression le …